ID T1P7X4_MUSDO Unreviewed; 680 AA.
AC T1P7X4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Neuroendocrine convertase 2 {ECO:0000313|RefSeq:XP_011295138.1};
DE SubName: Full=Subtilase family protein {ECO:0000313|EMBL:AFP59281.1};
GN Name=LOC101898851 {ECO:0000313|RefSeq:XP_011295138.1};
GN Synonyms=101898851 {ECO:0000313|EnsemblMetazoa:MDOA001135-PB};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP59281.1};
RN [1] {ECO:0000313|EMBL:AFP59281.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP59281.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP59281.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA001135-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001135-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_011295138.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; KA644652; AFP59281.1; -; mRNA.
DR RefSeq; XP_011295138.1; XM_011296836.2.
DR STRING; 7370.T1P7X4; -.
DR EnsemblMetazoa; MDOA001135-RB; MDOA001135-PB; MDOA001135.
DR VEuPathDB; VectorBase:MDOA001135; -.
DR eggNOG; KOG3526; Eukaryota.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..680
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014313683"
FT DOMAIN 517..653
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 222
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 263
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 438
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 680 AA; 74840 MW; 41ACFE9975E6532C CRC64;
MILTACVYPI TGLLLLCTLS GLTVVSSDDL KATVRNSDIS NLAKSATSSG PFRGRRPVAG
GNDVFTSSFL VRFRRSVDND YAHAVAQKYG FDNLGALVGG NGHEYHFKHR TLPHARSRRS
ITHTRLLKSH PMIHTAVQQP GFKRVKRGLR PAVHAIHGLK FDATYNTQAS TESAEPTDPY
FPFQWYLKNT GQNGGKARLD LNVQAAWDQG ITGKNVTTAI MDDGVDYMHP DLKFNYNAEA
SYDFSSNDPF PYPRYTDDWF NSHGTRCAGE VAAARDNGIC GVGVAYDSKI AGIRMLDQPY
MTDLIEANSM GHEPHKIHIY SASWGPTDDG KTVDGPRNAT MRAIVQGVNE GRNGLGNIYV
WASGDGGEED DCNCDGYAAS MWTISINSAI NDGQNAHYDE SCSSTLASTF SNGAKDPNTG
VATTDLYGKC TTTHSGTSAA APEAAGVFAL ALEANPELTW RDIQHLTVLT SKRNSLFDAK
NRFHWTMNGV GLEFNHLFGF GVLDAGGMVT LAKQWHTVPP RYHCEAGEIS ETHPIYSGRS
LFLEIKTDAC KGTDTEVNYL EHVQAVISAN ASRRGDLELF LTSPMGTRSM ILSRRANDDD
HRDGFTKWPF MTTHSWGEYP HGTWKLEARF NSNQPRSGWL IDWSLVLHGT KEAPYRTLSP
ASPHSKLAIV KKAHEEKKMQ
//
