ID T1P9F3_MUSDO Unreviewed; 786 AA.
AC T1P9F3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Low-density lipoprotein receptor repeat class B {ECO:0000313|EMBL:AFP59167.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP59167.1};
RN [1] {ECO:0000313|EMBL:AFP59167.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP59167.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP59167.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KA644538; AFP59167.1; -; mRNA.
DR AlphaFoldDB; T1P9F3; -.
DR VEuPathDB; VectorBase:MDOA006146; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:AFP59167.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AFP59167.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 371..414
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 416..459
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 558..592
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 747..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 17..29
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 24..42
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 66..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 111..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 123..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 582..591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 786 AA; 85992 MW; FF1D54081CF4C997 CRC64;
MSDEMGCPPR FPGGRYCPES RFQCSNNLCV SPSDLCDGTD DCGDGSDEDP KVCSDFNCDT
LRRFQCDNHR CVARYQICDG VDNCGDGSDE NNMTICASKV KPCDLYTQYQ CANKNCIDRA
QVCDYSDDCG DASDELGCHH NLSCLDDTRG GCQHHCHNLT DGGYICACYP GYIISNDNKK
KCVDVDECAT RQHTCSHQCH NLNGTYSCSC RDGFRLVDST SGVCKAEKED VVVIFSNGPE
IRALDLQKKD EYDVILSEKR IEALDYHAEQ QIVFWADSYD KTIKRSYMVN AVDGQARIGF
AQDLNMKGGS KPTAVAVDWL ANNLYWAEVD RTGSKPRGRV MVATTDGRYR RSIVNAGLEV
PTSIAVNPQL GRIYWSDAGS APKIEVSWMD GSKRRPIITE AIRHPAGLTI DYAQDHVIYW
VDTKLNTIES IKPDGSARKT VVKGDQLRHP VSLDIFESNM YWVTRDTGEL LKQDKFGRGV
QVAVHRNLVN PSGLKIYHEK RYNTSLKDPC FGSSCSHLCL LVPGGHRCAC PDSSGALPSH
RSTVEVICDA AAERPRPAPR ICPCQNGGFC VEDNNGELMC ECLADFKGDH CEQNAAGMFG
HGGANVTAVV VPIMVILLVL LAAGGVWFVI RKKPFGKLAR LPTLTSSQSV TFRQGTNVEF
NAPGFPGPTA PVGTSTGDVA PLEGYNLQTV NAGKTRDFSN PMYDAVQSGT TDPSISNGSG
IYEVPHDPSK TKPIGPFTEP VSAILAPSSI THKSSPQLQL RTRELDPSAD NGKDTQYLVE
EDKSEC
//
