ID T1PIY7_MUSDO Unreviewed; 590 AA.
AC T1PIY7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=101900192 {ECO:0000313|EnsemblMetazoa:MDOA012008-PA};
GN Synonyms=LOC101900192 {ECO:0000313|RefSeq:XP_005180919.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP63273.1};
RN [1] {ECO:0000313|EMBL:AFP63273.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP63273.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP63273.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA012008-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012008-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005180919.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005180919.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936,
CC ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU361242}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
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DR EMBL; KA648644; AFP63273.1; -; mRNA.
DR RefSeq; XP_005180919.1; XM_005180862.3.
DR STRING; 7370.T1PIY7; -.
DR EnsemblMetazoa; MDOA012008-RA; MDOA012008-PA; MDOA012008.
DR VEuPathDB; VectorBase:MDOA012008; -.
DR eggNOG; KOG3737; Eukaryota.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF68; N-ACETYLGALACTOSAMINYLTRANSFERASE 7; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|RuleBase:RU361242, ECO:0000313|EMBL:AFP63273.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 466..584
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 590 AA; 68276 MW; 0F565F590E44C511 CRC64;
MRISNIRNGR ICRLALLLIL LPLLYLLITW SDGHKRVQEV YQAKFGTGRR HYQRLEGRPK
EIPVLVEGLG NFEPTTLEER VGPGENGEAY HMPAHKKNEA DESEMEYGMN IAASDDISMH
RSVRDTRLEE CKHWNYPYDL PKTSVIIVFH NEGFSVLLRT VHSVIDRTPK HILHEIILVD
DYSDKKNLGE ELENYIKQFK GLVRLIRNKE REGLIRTRSR GAKEATGEVI VFLDAHCEVN
TNWLPPLLAP IYRDRTVMTV PIIDGIDYKT FEYRSVYGSE NHFRGIFEWG MLYKENEVPK
REQRRRQHNS EPYRSPTHAG GLFAINREYF LELGAYDPGL LVWGGENFEL SFKIWQCGGS
IEWVPCSHVG HVYRGFMPYN FGKLASKKKG PLITINYKRV IETWFDETHK EYFYTREPLA
RYLDMGDISE QLALKKRLNC KSFQWYMDNI AYDVYDKFPA LPANLQWGEL RSVATENCLD
SMGHQPPAIM GLSHCHGGGN NQLIRLNAAG QLGVGERCVE ADRQGIKLAV CRLGTTDGPW
SYDENTKHLL HRAHRKCVAV HPTTQQLFLA HCDVNDGYQQ WYFKPIKPNY
//
