ID T1PL43_MUSDO Unreviewed; 1276 AA.
AC T1PL43;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Laminin G domain protein {ECO:0000313|EMBL:AFP64096.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP64096.1};
RN [1] {ECO:0000313|EMBL:AFP64096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP64096.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP64096.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KA649467; AFP64096.1; -; mRNA.
DR EMBL; KA649669; AFP64298.1; -; mRNA.
DR AlphaFoldDB; T1PL43; -.
DR VEuPathDB; VectorBase:MDOA003118; -.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1276
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007729178"
FT TRANSMEM 1210..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..176
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 180..360
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 366..532
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 534..571
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 788..954
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 955..991
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 993..1175
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1246..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 144457 MW; 5216B4327A9051A0 CRC64;
MRNKFFAALL LYFNIFSFSS LRNVKADSYS DYFSDYECNT PLMEKASLSA TSALNDRGPE
KARLNAGTSW SAKNSDFDQR LIIDLGEVKN VTHIALQGRP HSNEFVTEYA ISYGISDLEF
ADYKEPGGNI KMFKGNSDGN SIHYNVFEVP IIAQWIRINP TRWHDRISMR VELYGCDYVA
ENLYFNGTGL IRYNLMQDPI ASTRESIRFR FKTANANGIM MYSRGTQGDY FALQLMENKM
VLNLDLGGGI MTSLSVGSLL DDNVWHDVVI SRNRRDIIFS VDRVIVRGRI KGEFSRLNLN
RELYLGGVPN IQEGIYVTQN YTGCMENIYF NSTNFIREMK DQHERGEFYR FSKINTVYAC
PSPPIYPVTF TTRGSFVRLK GYEGQKSLNV SFYFRTYENE GMMLHHDFAN GGYVRVFLEK
GKVKVDLKLA DKPRIILDNY DERFNDGKWH AFVLTIQRNR LVLDIDQRPM ATTKNIQIST
GRVYYIAGGM EKNNGFVGCM RLILVDGNYK LPKDWVQGEE VCCGDEVVVD ACQMIDRCNP
NPCQHNGHCH QDSTDFFCDC DNTGYAGAVC HTSNNPLSCQ ALKNVQHVSS RVTTKIDVDG
SGPLKPFPVT CEFYTDGRVI TTLSHSQEHT TTVDGFQEPG SFEQNILYDA DMQQIEALLN
RSHTCWQRLS YSCRSSRLFN SPSEVSNFRP FSWWVSRHNQ PMDYWAGALP GSRKCECGIL
GKCQDPTKWC NCDSNSLEWA EDGGDIREKE YLPVRAVKFG DTGTPLDEKQ GRYTLGPLRC
EGDDLFSNVV TFRIADATIN LPPFDMGHSG DIYLEFKTTV ENAVIFHATG PTDYIKLTIS
GGNKLQFQYQ AGSGPLGVNI ATSYHLNDNE WHTVSVERNR KEARLVVDGS IKAEVREPPG
PVRALHLTSD LVIGATTEYR DGYVGCIRAL LLNGKMVDLK QFGERGMYGI SSGCVGRCES
SPCLNNGTCI ERYDGYNCDC RWSAFKGPIC ADEIGVNLRS NSIIRYEFIE SFRSTIAENI
RVGFTTTIPK GFLLGFSSNI TGEYLTIQIS NSGHLRCVFD FGFERQEIIF PKKHFGLGQY
HDVRFSRKNS GSTVVLQVDN YEPVEYHFDI KASADAQFNN IQYMYIGKNL SMTDGFVGCV
SRVQFDDIYP LKLLFQQNPP PNVKSLGSQL TEDFCGVEPV THPPVEIETR PPPLVDEEKL
RKAYNEVDTA LLAILLIILF LLLILMIFLI GRYLHRHKGD YLTHEDQGAD GADDPDEAVV
HSTTGHQVTK RKEWFI
//
