ID T1PML3_MUSDO Unreviewed; 4624 AA.
AC T1PML3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Twitchin {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP64650.1};
RN [1] {ECO:0000313|EMBL:AFP64650.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP64650.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP64650.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KA650021; AFP64650.1; -; mRNA.
DR VEuPathDB; VectorBase:MDOA005249; -.
DR VEuPathDB; VectorBase:MDOA006932; -.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 24.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 45.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF9; TITIN; 1.
DR Pfam; PF00041; fn3; 24.
DR Pfam; PF07679; I-set; 20.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 24.
DR SMART; SM00409; IG; 21.
DR SMART; SM00408; IGc2; 18.
DR SUPFAM; SSF49265; Fibronectin type III; 12.
DR SUPFAM; SSF48726; Immunoglobulin; 21.
DR PROSITE; PS50853; FN3; 24.
DR PROSITE; PS50835; IG_LIKE; 16.
PE 2: Evidence at transcript level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 534..623
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 812..890
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 907..991
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1185..1282
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1288..1383
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1387..1477
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1485..1580
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1586..1681
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1685..1775
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1782..1880
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1886..1980
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1985..2077
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2085..2180
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2186..2281
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2285..2372
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2382..2476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2483..2578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2678..2771
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2777..2872
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2876..2965
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2973..3066
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3072..3167
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3267..3360
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3366..3465
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3469..3558
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3566..3659
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3665..3760
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3764..3855
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3861..3959
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3960..4054
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4058..4147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4155..4250
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4256..4350
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4452..4545
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4551..4624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 655..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2769..2788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 4624
FT /evidence="ECO:0000313|EMBL:AFP64650.1"
SQ SEQUENCE 4624 AA; 517668 MW; A5A57A2482F31047 CRC64;
MGVAEDFAPF FIKKPQLRQE DDGNRLIFEC QLQSSPAPNI EWYRSDTLVV ENERTKLRII
PIEGNKYTVL LEIDDVLDTD AGLYKVRAKN SSGEVSASIN LNFSQGNISF SHVLGQIDGF
APTFAKKPSI RQEDEGKRLL FECTVNADPQ PVITWFHNDK TVYESPRHKL SVKKDGHSYF
ATLELKNVTV EDAGKYKVNG KNDLGESNAT ISLNFDSTND ANGFAPSFIE KPKIVPNDSG
TLITMKCRCK AKPEPTVTWY RGKEVVNKSK KIGIKTAPIG EDSYELTLEI KDPGAADGGT
YRCNVKNEFG ESNANLNLNI EAEAEPDGEG PTFVEKPRIV SENSGKLIIM ECKVKADPKP
KIVWYRNNEI VNENNKIKMS VEQRGDHYYI KLEMIDPQIE DSGLYKCNIK NNLGELNANL
TLNIEIIPVI KDKPKIIKII KKRTVVIECT VASKYEPKCT WFKESNIVKE SSRHVCKVQR
SKEGEFAVQL EINDVDETDK GAYKLVASNE KGEAVSQIVH LIDIPEAERK PKKPEIDRKL
TDQRIVESKS FDLTIKLKET DRSCKIEWYK GSALIRETKE ITTTFDGTTA RLTFSAARVE
HTASYKVIVS NEVGKAESTC KVVVEKKQEK SQNEEQADVK RKKELFEKIG FKKTEQKTLQ
RKTEPQKVTK AQPPAPGEPP KIEVIREKRP SLVPEPTSRR GSLVPPDTGR RPSLIIDEKQ
ESFLSPLIDQ FAKEGKDKKV VFEARFSKPN CKPKWLFRKD ECFPGSKFKF KNENDTYQLI
ISNPKVEDTG KYTIEIGGVS STAFLNVEEA DPSYTFTKPL KKKMEGYTQH ETTLECSVSS
SMANVTWLKD GKKIESDDSR YLISKDINGN LKLIIKECVL EDSGLYTCQL DKQPDKTECK
LKIVEYPYKF VKVLKSQKCV EKDTVTLACE IDDATGEVQW WRNDEEIKPD KRIQIIKDGR
KRKLVIKDCK VSDSGMYKCT TNADKTEAEL IINYQNRFNK QLKNTDAVER EKLTLDVELQ
DQTAPCEWKF NGEPIEPSDR IEIKNLGGGK HQLVFNGLEL TDAGEISCES GQLKSTCKLT
VRKGESKPNI DCPNEFSGPI SSPVIVDVPY KVSGTKQTPV EAKLLKDGKA LPLKDVEVAI
ADEKVTFKIK KPTRDMSGLY QIKLSNGQGD DTKDVQIICQ DVPDSPNNID VTDVYQTSCK
INFSPPKDDG GSPITKYIIE RQDLSKKQAW ETVSEVLPTE PLTKDITDLV PKKQYRFRIR
AINAIGSSEP ATFKNTILAK DPWDEPGKPR NVDLTDWDKD HADLKWDAPE NDGGDKITSY
VIEFKEKFSN DWVVGKEVPS EQCSATVDGL KEGQQYEFRV RAVNRAGPGE PSDKTKSITA
KCRFVKPFIV GDDLKNITVK KGQTVRYEIK YDGEPEPEVS WYKGAQRLVF DNQRICSHQM
ERNTSITIKK ALRSDTGIYK LVLTNSSGSL ETEAQVTVLD RPLSPRGPLE PKEVRADHIT
VTWKPPEDDG GCEITGYAME RMDEETGRWV PAGEAGPNDT SFNFKGLTPG KKYKFRVKAI
NKEGESDPLE CTEPILAKNP YDPPSAPGKP IIDDYDNKSV VLKWKIPPSD GGRPIIYYII
EQKDKFSPSW VEVAKTDDAV PQCTVENLKE KMIYNFRVKA VNKAGPSEAS EPTDNHLCKH
KNLKPQIDRS TFKRVTIKSG RTHKWSVDVA GEPAPALNWS WRDNVPLTTG DRIKIEVVDY
HTDFTITKVI RKDSGMYTLK AENRSGTDTE TVELIVLGKP SSPRGPLAVN DVTATGCNLQ
WKKPEDDGGV PIKEYVVEKM DTATGKWIRI GRSPGEKEPP SFAVSGLNPG SEYMFRVSAV
NEEGESEPLT TLVGVVAKDP YTEPNKPGAP EVTDYDNESV SLKWSTPTND GGAPVEKYII
EKKPKNQKSW EKALEVPGDQ LEAKVNGLQE YEEYQFRVIA VNKAGPSQPS DASAPQVVKY
KKLKPRIDRT NLKPLLIRSG KPIKYDVKIR GEPVPTVIWY QNDKELKPEE LPSTCEIQNI
PHNTKISIID TARQHSGIYK IRAINEHGED EATVEVNVLG APGKPKGPLK VDNITKDSCK
LKWKKPDDDG GKPITAYQIE KFDKKQGRWV PVGRIPGTET EMDVKGLQEG HEYQFRVKAI
NDEGESEPLE TDTSIIAKNP YDIAEKPGKP TVTDYDSHFI KLSWEAPKND GGAPIIGYVI
EKKDKFSPHW DEVMSTDSPI TEAKVDGLVE GNVYQFRVRA INKAGVSEPS VASDPQVAKP
RNLKPNINRE KMKSVRVRAG QTIKFDVDVK GEPAPALKWT FKDVELLPLE GIRIETEEYN
TKLTLFDVTR KDSGKYKLSA ENINGRDEAD VDVIVLDKPS KPEGPLDVSD IYKDSCKLKW
KKPKDDGGIP ISGYVIEKLD TATGKWEAAG TVDPEKTEYD VKGLEQNHRY QFRVRAVNDE
GESEPLETDS AITAKNPFDV AAPPGLPEFE DWDEHHVKLK WEPPIRDGGA PITSYTIEVM
DKDSGEFVKA IETEGPICKG TVKKLEEGQQ YKFRIRANNK AGASEPSEQT NWHTAKPRYL
KPHIDRNKLK PLTVKAGLSI DLDINIKGEP APKVEWFFKG SPLENEEIKI ENVDYNTKLF
VMRAKRPMSG IYTIKASNEV GEDVADLDIM VLGKPGKPKG PLEVDNITKH GCKLKWQPPE
DNGGAPIDYY EIEKLDPHTG QWLPCGKSSE PNAKVTGLQE GKSYKFRVRA VNKEGESEDL
ETDKPIIAKN PYDEADKPGR PEPTNWDKDF VDLQWEPPKS DGGAPIEKYI IQMRDKSGRS
WVDAAITPGN HTKGTVTNVE EGHEYEFRIV AVNKAGPSEP SDVSKSVVAK PRHLKPRIDR
KNLQKKTLRS GQLLHIESIV NGEPPASVTW TFNGEVLKST DRIKIENEDY KTTFIIPKVK
RSDKGVYTVT AKNDSGTDTV ELELEVLCKP KAPKGPLEVS NVTSDSVTLK WEKPEDDGGQ
PIENYVVERM DTETGRWVPV LTTKSPEAQV SGLTEGKEYM FRVKAVNAEG ESEPLTTDVP
TLAKNPFDTA DSPGKPQIVD WSENHVDLKW KVPDDDGGAP ITGYVIEKKD CNTGKWQKAL
ETKTPANSAR VNDLIEGTKY QFRIRAVNDA GESKPSEPSD TLLAKCRFAP PKIDRTNIKD
ITTKFGTHVR LDIKISGEPP AVKTWYHNKA RIEGDDVTID LEPYKTKFTI PFAKRSHTGK
YTIKAENESG RDEASFEINI LDRPGQPEGP LRITDVHKEG CKLKWNPPLD SGGLPVDYYI
VEKMDVESGR WLPATRVKEP YAEVNNLVEG QEYKFRVVAV NTEGESEPLN GDHSIIAKNP
FDVPGKPGAP EPVDWDKDHV DIVWKPPIND GGSPITAYSI EKKEDGSDKW IKVLEVQAPI
QGEDCKATVS YLDENCKYEF RVRAINAAGS GEPSNASKSV ITKPSKLAPK IDRRNIHTYN
VKSGESILLD ITVEGEPAPD VYWTHNGKSI QQSTSRKVNN APYKTKYNNS NLERKDTGIY
KIVASNLYGH DEVEFQINVI TKPSKPEGPL EVSDIHKEGC KLKWKRPKDD GGEPIEEYVV
EKFDPTEGVW IQCGKSAIPE FNVEGLRPGC EYKFRVKAVN KEGESEPLET LSSIIAKDPF
TTPSAPGAPE PVDWSSNKVE LTWSEPLTDG GSPIIGYIIE KKDKYSPIWE KALETDNPLP
NATINGLVEG NEYQFRVVAL NKAGYSEPSE ASKSFVAKPR FLEPKIDRRY LRDITVSAGS
SIKLEAVITG EPAPKVEWRY SNCPLQNGKT VTIESPDYFT KLVIRPAQRE DSGEYVVTAT
NSSGKDIVKI NVVVTDKPSA PTGPLSITDV HKEGCHLKWK RPKDDGGIPI EYYQIEKMDV
ETGCWVPCCR SVEPQADVVG LKCGSEYKFR VSAINAEGES EFLVGDESVI AKNLFDEPDK
PQNVHPVDWD KDHIDLAWTP PSHDGGSPIT GYIIEMRDKY GHWERALEVP SDTLKASVKN
VIEGQTYEFR VIAANSAGLS EPSETTNPIT AKARNKAPLI DRTNLCEIRI KAGQSFSYEC
KISGEPAPKT KWTHNKRELY SKDNIKVKHV DYYSKIKVTN ATRSDSGTYT IHAENENGVD
FADVKVIVID KPSPPNGPLK VNEIHASGCT LTWNPPDDDG GQPVTNYVIE KFDELIGRWV
PAGETDDNNT SFEVKGLTPD HKYKFRVRAK NRQGISDPLT STHSIVAKNP YDTPSKPGVP
IIKDFDKDFV ELEWTRPECN GGTPVTGYII EKRGKYGTDW EPCAKVEGDN TNGRVEDLIE
GNSYEFRVRA INKAGAGEPS DGSASHVARP RNLPPIIDKN YMLDIKIRAG NCFEFDVPVS
GEPDPSKEWS QDNNFIINTD RLKIVNEMHR TKLRVIDAKR ADSGEYTLIA RNINGIDKAT
VKVVVLDIPS IPEGPLRIDD ITKNSLNLHW RPPRDDGGSD ITHYIVEKMD TDAMRWIPVA
ECNECHIRAD NLIEGHDYNF RVRAVNKQGA SQPLLSSQGV TIKDPFSRPD KPGQPQAVDW
GKDFVDLEWP VPKRDGGSPI IGYVIEKRKK FGQWENALDD VTPQNKARVK NLTEGCEYEF
RVIA
//
