ID T1TEG7_9FLAV Unreviewed; 574 AA.
AC T1TEG7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS dengue virus type 1.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus denguei;
OC Dengue virus.
OX NCBI_TaxID=11053 {ECO:0000313|EMBL:AGT63084.1};
RN [1] {ECO:0000313|EMBL:AGT63084.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SV437_Laos_2009 {ECO:0000313|EMBL:AGT63084.1};
RX PubMed=23951379; DOI=10.1371/journal.pntd.0002360;
RA Dubot-Peres A., Vongphrachanh P., Denny J., Phetsouvanh R., Linthavong S.,
RA Sengkeopraseuth B., Khasing A., Xaythideth V., Moore C.E., Vongsouvath M.,
RA Castonguay-Vanier J., Sibounheuang B., Taojaikong T., Chanthongthip A.,
RA de Lamballerie X., Newton P.N.;
RT "An epidemic of dengue-1 in a remote village in rural laos.";
RL PLoS Negl. Trop. Dis. 7:e2360-e2360(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004367}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004367}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00004367}. Host endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00023443}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00023443}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00023443}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004385}.
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DR EMBL; KC182090; AGT63084.1; -; Genomic_RNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd12149; Flavi_E_C; 1.
DR Gene3D; 1.20.1280.260; -; 1.
DR Gene3D; 2.60.40.350; -; 1.
DR Gene3D; 1.10.8.970; Flavivirus envelope glycoprotein M-like; 1.
DR Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1.
DR Gene3D; 3.30.67.10; Viral Envelope Glycoprotein, domain 2; 1.
DR Gene3D; 3.30.387.10; Viral Envelope Glycoprotein, domain 3; 1.
DR InterPro; IPR000069; Env_glycoprot_M_flavivir.
DR InterPro; IPR038302; Env_glycoprot_M_sf_flavivir.
DR InterPro; IPR013755; Flav_gly_cen_dom_subdom1.
DR InterPro; IPR027287; Flavi_E_Ig-like.
DR InterPro; IPR026470; Flavi_E_Stem/Anchor_dom.
DR InterPro; IPR038345; Flavi_E_Stem/Anchor_dom_sf.
DR InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer.
DR InterPro; IPR001157; Flavi_NS1.
DR InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf.
DR InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR InterPro; IPR013756; GlyE_cen_dom_subdom2.
DR InterPro; IPR014756; Ig_E-set.
DR NCBIfam; TIGR04240; flavi_E_stem; 1.
DR Pfam; PF21659; Flavi_E_stem; 1.
DR Pfam; PF02832; Flavi_glycop_C; 1.
DR Pfam; PF00869; Flavi_glycoprot; 1.
DR Pfam; PF01004; Flavi_M; 1.
DR Pfam; PF00948; Flavi_NS1; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
PE 4: Predicted;
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022506};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..54
FT /note="Envelope glycoprotein M flavivirus"
FT /evidence="ECO:0000259|Pfam:PF01004"
FT DOMAIN 56..350
FT /note="Envelope glycoprotein E central and dimerisation"
FT /evidence="ECO:0000259|Pfam:PF00869"
FT DOMAIN 352..447
FT /note="Glycoprotein E immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF02832"
FT DOMAIN 450..544
FT /note="Flavivirus envelope glycoprotein E Stem/Anchor"
FT /evidence="ECO:0000259|Pfam:PF21659"
FT DOMAIN 551..574
FT /note="Non-structural protein NS1 flavivirus"
FT /evidence="ECO:0000259|Pfam:PF00948"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT63084.1"
FT NON_TER 574
FT /evidence="ECO:0000313|EMBL:AGT63084.1"
SQ SEQUENCE 574 AA; 62402 MW; F0DDEC47DAB12C4A CRC64;
SEGAWKQIQR VETWALRHPG FTVIALFLAH AIGTSITQKG IIFILLMLVT PSMAMRCVGI
GSRDFVEGLS GATWVDVVLE HGSCVTTMAK DKPTLDIELL KTEVTNPAVL RKLCIEAKIS
NTTTDSRCPT QGEATLVEEQ DANFVCRRTF VDRGWGNGCG LFGKGSLITC AKFKCVTKLE
GKIVQYENLK YSVIVTVHTG DQHQVGNEST EHGTTATITP QAPTTEIQLT DYGALTLDCS
PRTGLDFNEM VLLTMKEKSW LVHKQWFLDL PLPWTSGAST SQETWNRQDL LVTFKTAHAK
KQEVVVLGSQ EGAMHTALTG ATEIQASGTT TIFAGHLKCR LKMDKLTLKG MSYVMCTGSF
KLEKEVAETQ HGTVLLQIKY EGTDAPCKIP FSTQDEKGVT QNGRLITANP IVTDKEKPVN
IEAEPPFGES YIVIGAGEKA LKLSWFKKGS SIGKMFEATA RGARRMAILG DTAWDFGSIG
GVFTSVGKLV HQIFGTAYGV LFSGVSWTMK IGIGVLLTWL GLNSRSTSLS MTCIAVGLVT
LYLGVMVQAD SGCVINWKGR ELKCGSGIFV TNEV
//
