ID T1UA95_HELPX Unreviewed; 498 AA.
AC T1UA95;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HPSA20_0966 {ECO:0000313|EMBL:AGT74199.1};
OS Helicobacter pylori SouthAfrica20.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1352356 {ECO:0000313|EMBL:AGT74199.1, ECO:0000313|Proteomes:UP000015920};
RN [1] {ECO:0000313|EMBL:AGT74199.1, ECO:0000313|Proteomes:UP000015920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SouthAfrica20 {ECO:0000313|EMBL:AGT74199.1};
RX PubMed=24072860;
RA Duncan S.S., Bertoli M.T., Kersulyte D., Valk P.L., Tamma S., Segal I.,
RA McClain M.S., Cover T.L., Berg D.E.;
RT "Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori.";
RL Genome Announc. 1:e00729-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
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DR EMBL; CP006691; AGT74199.1; -; Genomic_DNA.
DR AlphaFoldDB; T1UA95; -.
DR KEGG; hpys:HPSA20_0966; -.
DR PATRIC; fig|1352356.3.peg.949; -.
DR HOGENOM; CLU_004585_5_10_7; -.
DR Proteomes; UP000015920; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..101
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 102..419
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 498 AA; 56501 MW; 742DE84AFB62CE8B CRC64;
MKNTKKKHNY IDYNDLLLLF KKAMLETPSP YKEVLCDEFQ DTNPLQESIL DAINPPSLFC
VGDYDQSIYA FNGADISIIS NFTQKYKNAR VFTLTKNYRS SKEILDLANQ VIQHNQRIYP
KNLEVVKSGD FNKPTLLNYD DNIAQCQDIA KRIVMRKNFK EVAVIFRNNA SADQLEAALR
ANNVPSKRKG SASFFESKEV ALALDICTLV FNPKDIMAAI HVLSYANDIG SNTAKDIHEA
LMLLGNGDLK SALTHPNKEA KIYTKKKEIT SMGLFEEIFA LENSSRFNSV IAKAFHSHPI
LMHPKISLNG AKMLSDFFTL YTHAPNSPSA LIKHTIESAF FQTIKTRLLK ERSKNKDGSY
NEFKKLQAQK RFNEKMELLS SLAKNYQDLG RFLNGTLIGS NEATQGEGVN LLSVHASKGL
EFKDVYIIDL MEGRFPNHKL MNTGGGIEEE RRLFYVAITR AKENLWLSYA KNELRENAKP
KEHKPSVFLY EAGLLKPQ
//
