ID T1VZZ9_HORWE Unreviewed; 684 AA.
AC T1VZZ9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Putative potassium channel isoform 1A {ECO:0000313|EMBL:AGT96003.1};
GN Name=TOK1A {ECO:0000313|EMBL:AGT96003.1};
GN ORFNames=D0859_10308 {ECO:0000313|EMBL:RMZ25643.1};
OS Hortaea werneckii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX NCBI_TaxID=91943 {ECO:0000313|EMBL:AGT96003.1};
RN [1] {ECO:0000313|EMBL:AGT96003.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EXF-2000 {ECO:0000313|EMBL:AGT96003.1};
RA Lenassi M., Gostincar C., Plemenitas A., Gunde-Cimerman N.;
RT "Whole genome duplication and enrichment of metal cation transporters
RT revealed by de novo genome sequencing of extremely halotolerant black yeast
RT Hortaea werneckii.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RMZ25643.1, ECO:0000313|Proteomes:UP000281677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-120 {ECO:0000313|EMBL:RMZ25643.1,
RC ECO:0000313|Proteomes:UP000281677};
RX PubMed=29764372; DOI=10.1186/s12864-018-4751-5;
RA Gostincar C., Stajich J.E., Zupancic J., Zalar P., Gunde-Cimerman N.;
RT "Genomic evidence for intraspecific hybridization in a clonal and extremely
RT halotolerant yeast.";
RL BMC Genomics 19:364-364(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|RuleBase:RU003857}.
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DR EMBL; KC961326; AGT96003.1; -; Genomic_DNA.
DR EMBL; QWIT01000342; RMZ25643.1; -; Genomic_DNA.
DR AlphaFoldDB; T1VZZ9; -.
DR VEuPathDB; FungiDB:BTJ68_06081; -.
DR Proteomes; UP000281677; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:AGT96003.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 69..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..313
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 394..471
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 13..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 76329 MW; 0F25360E67270DCA CRC64;
MKVKKWLFLP FLGGSSDRDR GPRRDRSRSR SRRPSRPENG ALVKHESADA FANKGEEELV
QDYNAPIRWY MLATLFPLIA GTFGPMASMF NICAIAIPWR LIVDPSSPQS QGEHINDPRW
LVAVNIVSLV IAILANVALL GQMTNRLRFN VASPVTIVGW YISGFIDIAL AAVAPSQVPL
PADNALATYS QAYYYCIFSG AIYVLLSIML SCTAWGVWIG NYSSEFKLSL AQRSLMLQTI
LFLAYVLAAG GVYARVEGWD FLNSVYYIIV TLFTIGFGDF SPETHTGRSL YFPMSVGGII
FVGLIIANIR SLVLESTSVK VSTRLVERMR YKSIKAGNPQ DGIVKVRGVL HRDTNAPTEL
ARREKEFDVM REIQAAAAHN NRMIALSMAT MAFMILWFIG SVCFWQAEKA VGGRNWSYFE
ALYFTYTAQL TIGYGDFGPQ TNSAKPTFVF WSLIALPTLT VLIGAVGDAV TDFVNWYTLW
LGKHAPNVFK ILTGMKKRSS VDDTFQEAIE KVGAEIEGSN TNGSGFHNIA DIETGRVVPA
EITDTAFGHV RLGTVEEAYK PFLMLQAARK AIEHLDEESP RKYTFQEWSW ILKLLGEDEA
TEENHRRVGQ PVPENAEVAT PVCLSPHQVW SWMGQESPLM SLEEGSEPKW VLKRLMEVLE
LELKRRGDLH VAKEADITSK AGDR
//
