ID T1YT96_9TRYP Unreviewed; 293 AA.
AC T1YT96;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:AGU67963.1};
DE EC=1.1.1.169 {ECO:0000313|EMBL:AGU67963.1};
OS Angomonas desouzai.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Angomonas.
OX NCBI_TaxID=59800 {ECO:0000313|EMBL:AGU67963.1};
RN [1] {ECO:0000313|EMBL:AGU67963.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TCC079E {ECO:0000313|EMBL:AGU67963.1};
RX PubMed=24260300;
RA Klein C.C., Alves J.M., Serrano M.G., Buck G.A., Vasconcelos A.T.,
RA Sagot M.F., Teixeira M.M., Camargo E.P., Motta M.C.;
RT "Biosynthesis of vitamins and cofactors in bacterium-harbouring
RT trypanosomatids depends on the symbiotic association as revealed by genomic
RT analyses.";
RL PLoS ONE 8:E79786-E79786(2013).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; KF160119; AGU67963.1; -; Genomic_DNA.
DR AlphaFoldDB; T1YT96; -.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00745; apbA_panE; 1.
DR PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:AGU67963.1};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..293
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004586430"
FT DOMAIN 5..147
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 176..282
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 293 AA; 32237 MW; 95745250AD610CB3 CRC64;
MKTVGLIGLG ALGIMFGWQL QQKLGNDFCV IVDEERKETY LRQGIFANGE PCQFRFVTPQ
QASEPLDLLI FGTKIGGLRA AIATAKPFVG PTTVVLSLLN GVSSEEIIGE SYGAEKVLLA
VSQEMDAVRV GTGVRYTNMG CIVYGEPNGE LTARVTEVER ILQKGGVVGR PSREAKRILW
NKLMINVGVN QVSAAYNATY GDICKKPEVH EVFLGAMREA MMIGCKEGVD LSEDDVARWI
SLVEKLDPNS FPSMLQDVRA KRYTEVELFG KTIVQLGKKS EFPPRSIRCL SRK
//
