ID   T2BMZ8_CROPO            Unreviewed;        42 AA.
AC   T2BMZ8;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Lactate dehydrogenase A {ECO:0000313|EMBL:AGV12736.1};
DE   Flags: Fragment;
GN   Name=LDH-A {ECO:0000313|EMBL:AGV12736.1};
OS   Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Longirostres; Crocodylidae;
OC   Crocodylus.
OX   NCBI_TaxID=8502 {ECO:0000313|EMBL:AGV12736.1};
RN   [1] {ECO:0000313|EMBL:AGV12736.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nunu {ECO:0000313|EMBL:AGV12735.1}, and Sue
RC   {ECO:0000313|EMBL:AGV12736.1};
RA   Hauswaldt J.S., Vences M., Louis E., Brennemann R., Ziegler T.;
RT   "Genetic screening of captive Philippine crocodiles (Crocodylus
RT   mindorensis) as prerequisite for starting a conservation breeding program
RT   in Europe.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interconverts simultaneously and stereospecifically pyruvate
CC       and lactate with concomitant interconversion of NADH and NAD(+).
CC       {ECO:0000256|ARBA:ARBA00033729}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC         Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23445;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23446;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KC849207; AGV12735.1; -; Genomic_DNA.
DR   EMBL; KC849208; AGV12736.1; -; Genomic_DNA.
DR   AlphaFoldDB; T2BMZ8; -.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF10; L-LACTATE DEHYDROGENASE A CHAIN; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
PE   4: Predicted;
FT   DOMAIN          1..42
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGV12736.1"
FT   NON_TER         42
FT                   /evidence="ECO:0000313|EMBL:AGV12736.1"
SQ   SEQUENCE   42 AA;  4690 MW;  5BDE813954569ADD CRC64;
     GMYGIKDDVF LSVPCVLGYH GITDVVMMTL KSEEEEKLRK SA
//