ID T2BNX7_CRYNH Unreviewed; 431 AA.
AC T2BNX7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=CNAG_02420 {ECO:0000313|EMBL:AGV14403.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AGV14403.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AGV14403.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003825; AGV14403.1; -; Genomic_DNA.
DR RefSeq; XP_012050138.1; XM_012194748.1.
DR AlphaFoldDB; T2BNX7; -.
DR GeneID; 23886042; -.
DR KEGG; cng:CNAG_02420; -.
DR VEuPathDB; FungiDB:CNAG_02420; -.
DR OrthoDB; 53554at2759; -.
DR Proteomes; UP000010091; Chromosome 6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12673:SF270; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..431
FT /note="DH domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004597881"
FT DOMAIN 60..281
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 431 AA; 48330 MW; 360CC8F6A4EA78AB CRC64;
MGFRRFLASL LCVSKAQADT DSILPITKDF ITSSSSISSA STASMRTSNR SQQILDKASG
RAMVIQEFIS SEETYVNLLE EFDDIYIQSA CAPLTFGTGG KLSREVTLDT ALTPDERRTM
FNGLQEILSL HRKLVLPKFF AATQVLLTQG DDRDGLRSTH AAFEVCQVIC KFADLFKMYS
AYSATCDNAT AKLTQWTNRA DMVRQDKNRV QAYLAKCKVN KKHSQINMTG YLLLPVQRLT
RYKMLLEQLE KYTPAPPTGT RDYIGEALAR ISAILVYVND YKRDLDARSR LCHWADQISS
VGPSPLVQPH RTLIREGPVN FIARGALPQN TSRTLKHRHV DESKRSIGTV NKMCMAILCQ
DLLVLVDNVA NKQKGKLELV DVVRLSAMGK ARVEWGNVVV FEAYDVSYYL QADDQEIAQG
WVDAINKSTR S
//
