ID T2EA_PONAB Reviewed; 439 AA.
AC Q5R8H5;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-APR-2013, entry version 56.
DE RecName: Full=General transcription factor IIE subunit 1;
DE AltName: Full=Transcription initiation factor IIE subunit alpha;
DE Short=TFIIE-alpha;
GN Name=GTF2E1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates
CC the RNA polymerase II C-terminal domain kinase and DNA-dependent
CC ATPase activities of TFIIH. Both TFIIH and TFIIE are required for
CC promoter clearance by RNA polymerase (By similarity).
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains. Interacts with
CC TAF6/TAFII80 (By similarity). Interacts with ATF7IP (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- SIMILARITY: Belongs to the TFIIE alpha subunit family.
CC -!- SIMILARITY: Contains 1 HTH TFE/IIEalpha-type domain.
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DR EMBL; CR859777; CAH91935.1; -; mRNA.
DR RefSeq; NP_001127483.1; NM_001134011.1.
DR UniGene; Pab.12968; -.
DR HSSP; P29083; 1VD4.
DR ProteinModelPortal; Q5R8H5; -.
DR SMR; Q5R8H5; 113-174, 394-439.
DR PRIDE; Q5R8H5; -.
DR Ensembl; ENSPPYT00000015701; ENSPPYP00000015098; ENSPPYG00000013500.
DR GeneID; 100174557; -.
DR KEGG; pon:100174557; -.
DR CTD; 2960; -.
DR GeneTree; ENSGT00390000016696; -.
DR HOVERGEN; HBG008614; -.
DR InParanoid; Q5R8H5; -.
DR KO; K03136; -.
DR OMA; QNVVISM; -.
DR OrthoDB; EOG47D9G9; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR017919; TFIIE/TFIIEa_HTH.
DR InterPro; IPR002853; TFIIE_asu.
DR InterPro; IPR021600; TFIIE_asu_C.
DR InterPro; IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR013137; Znf_TFIIB.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF11521; TFIIE-A_C-term; 1.
DR Pfam; PF02002; TFIIE_alpha; 1.
DR SMART; SM00531; TFIIE; 1.
DR PROSITE; PS51344; HTH_TFE_IIE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Complete proteome; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 439 General transcription factor IIE subunit
FT 1.
FT /FTId=PRO_0000260324.
FT DOMAIN 14 104 HTH TFE/IIEalpha-type.
FT ZN_FING 129 157 C4-type (Potential).
FT COMPBIAS 378 393 Asp/Glu-rich (acidic).
FT MOD_RES 2 2 N-acetylalanine (By similarity).
FT MOD_RES 67 67 N6-acetyllysine (By similarity).
FT MOD_RES 268 268 Phosphoserine (By similarity).
SQ SEQUENCE 439 AA; 49531 MW; EB3D21B2FF8EA8EC CRC64;
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN PCVKEEDMLE LLKFDRKQLR
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA
TKGPSYEDLY TQNVVINMDD HEDLHRASLE GKSAKERPIW LRESTVQGAY SSEDMKEGGI
DMDAFQEHEE GRAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTTAN GSDSESETSE
SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP
EEKEAYIAMG QRMFEDLFE
//
