ID T2FSK5_SIV Unreviewed; 879 AA.
AC T2FSK5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095};
DE Contains:
DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095};
DE Short=SU {ECO:0000256|RuleBase:RU363095};
DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095};
DE Short=gp120 {ECO:0000256|RuleBase:RU363095};
DE Contains:
DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095};
DE Short=TM {ECO:0000256|RuleBase:RU363095};
GN Name=env {ECO:0000313|EMBL:AGW03677.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AGW03677.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGW03677.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SIVmac251 {ECO:0000313|EMBL:AGW03677.1};
RX PubMed=25398324; DOI=10.4049/jimmunol.1401504;
RA Gordon S.N., Doster M.N., Kines R.C., Keele B.F., Brocca-Cofano E.,
RA Guan Y., Pegu P., Liyanage N.P., Vaccari M., Cuburu N., Buck C.B.,
RA Ferrari G., Montefiori D., Piatak M.Jr., Lifson J.D., Xenophontos A.M.,
RA Venzon D., Robert-Guroff M., Graham B.S., Lowy D.R., Schiller J.T.,
RA Franchini G.;
RT "Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in
RT protection from SIVmac251 vaginal acquisition and persistent viremia.";
RL J. Immunol. 193:6172-6183(2014).
RN [2] {ECO:0000313|EMBL:AIZ11670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=23P668.05Sep2012p8k21 {ECO:0000313|EMBL:AIZ11670.1};
RA Vaccari M., Keele B.F., Franchini G.;
RT "Adjuvant dependent functional mucosal antibodies to V2 and RAS activation
RT in vaccine protection from SIVmac251 acquisition.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: The mature envelope protein (Env) consists of a homotrimer of
CC non-covalently associated gp120-gp41 heterodimers. The resulting
CC complex protrudes from the virus surface as a spike.
CC {ECO:0000256|RuleBase:RU363095}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is present in
CC many retroviral envelope proteins. Synthetic peptides derived from this
CC relatively conserved sequence inhibit immune function in vitro and in
CC vivo. {ECO:0000256|RuleBase:RU363095}.
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DR EMBL; KF647051; AGW03677.1; -; Genomic_DNA.
DR EMBL; KM350980; AIZ11670.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|RuleBase:RU363095};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685,
KW ECO:0000256|RuleBase:RU363095}; Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|RuleBase:RU363095};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511,
KW ECO:0000256|RuleBase:RU363095};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046,
KW ECO:0000256|RuleBase:RU363095};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870,
KW ECO:0000256|RuleBase:RU363095};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581,
KW ECO:0000256|RuleBase:RU363095};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363095};
KW Transmembrane {ECO:0000256|RuleBase:RU363095};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363095};
KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095};
KW Viral envelope protein {ECO:0000256|RuleBase:RU363095,
KW ECO:0000313|EMBL:AGW03677.1};
KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095};
KW Virion {ECO:0000256|RuleBase:RU363095};
KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095}.
FT TRANSMEM 693..715
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363095"
FT DOMAIN 24..525
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 543..737
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 726..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 637..664
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 726..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 101015 MW; E50AF1EEEC91F0BE CRC64;
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD
NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDK
WGLTKSSTTT ASTTTTTAPA KIDMVNETSS CITHDNCTGL EQEQMIGCKF NMTGLKRDKT
KEYNETWYST DLVCEQGNST DNESRCYMNH CNTSIIQESC DKHYWDTIRF RYCAPPGYAL
LRCNDTNYSG FMPKCSKVVV SSCTRMMETQ TSTWFGFNGT RAENRTYIYW HGRDNRTIIS
LNKYYNLTMK CRRPGNKTVL PVTIMSGLVF HSQPVNERPN QAWCWFGGNW KDAIKEVKQT
IVKHPRYTGT NNTDKINLTA PRGGDPEVTF MWTNCRGEFL YCKMNWFLNW VEDRDLTTQR
PKERHRRNYV PCHIRQIINT WHKVGKNVYL PPREGDLTCN STVTSLIANI DWTDGNQTNI
TMSAEVAELY RLELGDYKLV EITPIGLAPT DVKRYTTGGT SRNKRGVFVL GFLGFLATAG
SAMGAASLTL TAQSRTLLAG IVQQQQQLLD VVKRQQELLR LTVWGTKNLQ TRVTAIEKYL
KDQAQLNAWG CASRQVCHTT VPWPNASLTP DWNNDTWQEW ERKVDFLEEN ITALLEEAQI
QQEKNMYELQ KLNSWDVFGN WFDLASWIRY IQYGIYIVVG VILLRIVIYI VQMLAKLRQG
YRPVFSSPPS YSQQTHIQQD PALPTREGKE GDGGESGGNS SWPWQIEYIH FLIRQLIRLL
TWLFNNCRTL LSRAYQILQP ILQRLSAALQ RIREVLRTEL TYLQYGWSYF HEAVQAGWRS
ATETLAGAWG DLWETLRRGG RWILAIPRRI RQGLELTLL
//
