ID T2HRB7_FRAOC Unreviewed; 511 AA.
AC T2HRB7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Nicotinic acetylcholine receptor alpha 8 isoform 2 {ECO:0000313|EMBL:BAN81843.1};
GN Name=nAChRa8 {ECO:0000313|EMBL:BAN81843.1};
OS Frankliniella occidentalis (Western flower thrips) (Euthrips occidentalis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Thysanoptera; Terebrantia; Thripoidea; Thripidae;
OC Frankliniella.
OX NCBI_TaxID=133901 {ECO:0000313|EMBL:BAN81843.1};
RN [1] {ECO:0000313|EMBL:BAN81843.1}
RP NUCLEOTIDE SEQUENCE.
RA Minakuchi C., Inano Y., Shi X., Song D., Zhang Y., Miura K., Miyata T.,
RA Gao X., Tanaka T., Sonoda S.;
RT "Neonicotinoid resistance and cDNA sequences of nicotinic acetylcholine
RT receptor subunits of the western flower thrips Frankliniella occidentalis
RT (Thysanoptera: Thripidae).";
RL Appl. Entomol. Zool. (Jpn.) 48:507-513(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily.
CC {ECO:0000256|ARBA:ARBA00009237}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; AB748925; BAN81843.1; -; mRNA.
DR AlphaFoldDB; T2HRB7; -.
DR SMR; T2HRB7; -.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19031; LGIC_ECD_nAChR_proto_alpha-like; 1.
DR CDD; cd19064; LGIC_TM_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF865; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:BAN81843.1};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..511
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004589475"
FT TRANSMEM 274..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 305..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 339..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 50..273
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 280..410
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 511 AA; 58581 MW; 1245F9AE10F3A4AC CRC64;
MAPSPSASKM TFRRRLNLCA RLALLAFVFS VARPPSVDGM KQIEANPDAK RLYDDLLSHY
NRLIRPVVNN TETLTVHLGL RLSQLIEVNM KNQVMTTNLW VEQKWVDYKL RWNPDHYGGV
EELYVPSEHI WLPDIVLYNN ADGNYEVTLM TKATVKYTGE VYWKPPAIYK SSCKINVLYF
PFDEQSCDMK FGSWTYNGFQ VDLKHIDQDT GSNLVHNGIN LKEFYLSVEW DILDAPARRN
EEYEPSTCCA NNDTTCCVPF SDITFNLTLR RKTLFYTINL IVPCVGITFL TVLVFYLPSA
SGEKVSLCIS ILLSLTVFFL LLAEIIPPTS LAVPLLGKYL LFTMILVTLS IFVTVCVLNV
HFRSPSTHRM SPWVQRVFLD VMPRFLLMRR PPYSSREPFI EDQYADNGYT NEMDCFRDSV
SDPFSPDFKS SGFESGTGLL QQQPHSAGEY TRRTRAADLS GCFLDRYARP ARSSRQSHFT
SHFCKILLHI PQLLKGFFFL LQTTIFFTQA A
//
