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Database: UniProt
Entry: T2HWL0_PIG
LinkDB: T2HWL0_PIG
Original site: T2HWL0_PIG 
ID   T2HWL0_PIG              Unreviewed;       711 AA.
AC   T2HWL0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx2 {ECO:0000256|ARBA:ARBA00039835};
DE   AltName: Full=Myxovirus resistance protein 2 {ECO:0000256|ARBA:ARBA00042030};
GN   Name=MX2 {ECO:0000313|EMBL:BAN84466.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:BAN84466.1};
RN   [1] {ECO:0000313|EMBL:BAN84466.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sasaki K., Tungtrakoolsub P., Morozumi T., Uenishi H., Kawahara M.,
RA   Watanabe T.;
RT   "A single nucleotide polymorphism of porcine MX2 gene provides antiviral
RT   activity against vesicular stomatitis virus.";
RL   Immunogenetics 66:25-32(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR   EMBL; AB854070; BAN84466.1; -; mRNA.
DR   AlphaFoldDB; T2HWL0; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF46; INTERFERON-INDUCED GTP-BINDING PROTEIN MX2; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003932}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          112..383
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          619..710
FT                   /note="GED"
FT                   /evidence="ECO:0000259|PROSITE:PS51388"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  80286 MW;  9C8F0084C3D1D531 CRC64;
     MPKPRMSWPY QRHRQASSPP HPHKEMNFFP QQPLPLGAGP GQMTFPLNWQ MGGKDLTKGL
     NMLTLSPQQP GGKSGQQTSK GPENNLYSPF EEKVRPCIDL IDSLRALGVE QDLALPTIAV
     IGDQSSGKSS VLEALSGVPL PRGSGIITRC PLALRLKKKE CPWQGRISYR KVELQLQDPS
     QVEREIRKAQ DAIAGSGVGI SHELISLEVT SPEVPDLTLI DLPGITRVAV GNQPQDIGLQ
     IKALIRKYIQ EQQAINLVVV PCNVDIATTE ALRMAQEVDP EGDRTIGILT KPDLVDTGAE
     KVVLNVMQNL TYHLKKGYMI VKCRGQQEIL NKLSLAEATK REIAFFHSHP HFRILLEEGK
     ATVPRLAERL TVELIGRISK SLPLLFSQIK EIHQSATEEL RLCGASVPSN DADKMFFLIE
     KIKVFNQDIE NLAEGEEIVK EKEARLYNKI REEFKSWIVT LDCNSKKVKN IIHEEVSKYD
     RQYRGKELMG FVSYKTFESI VRQYLEELVD PALGMLQAVV EIVRQTFSDT AQKNFGEFSN
     LNQTTQNKVD SIAARAAERA EGLIRLQFRM EQLVFCQDDI YRVDLKAVRE ELFNPVAEHP
     QSLQLRLPFV NGPSPVSSIT EIGVHVNAYF MGTSQRLANQ IPFIIQYCVL QESRDHLQKA
     MMQMLQGREQ YSWLLQEESH TSAKRHFLKE KIHRLAEARH TLSKFAQSLQ G
//
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