ID   T2M4G5_HYDVU            Unreviewed;       788 AA.
AC   T2M4G5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Tuftelin-interacting protein 11 {ECO:0000313|EMBL:CDG66805.1, ECO:0000313|RefSeq:XP_012559008.1};
GN   Name=TFIP11 {ECO:0000313|EMBL:CDG66805.1};
GN   Synonyms=LOC100199563 {ECO:0000313|RefSeq:XP_012559008.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG66805.1};
RN   [1] {ECO:0000313|EMBL:CDG66805.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG66805.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
RN   [2] {ECO:0000313|RefSeq:XP_012559008.1}
RP   IDENTIFICATION.
RC   STRAIN=105 {ECO:0000313|RefSeq:XP_012559008.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR017706}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family.
CC       {ECO:0000256|ARBA:ARBA00010900, ECO:0000256|PIRNR:PIRNR017706}.
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DR   EMBL; HAAD01000573; CDG66805.1; -; mRNA.
DR   RefSeq; XP_012559008.1; XM_012703554.1.
DR   EnsemblMetazoa; XM_012703554.1; XP_012559008.1; LOC100199563.
DR   EnsemblMetazoa; XM_012703554.2; XP_012559008.1; LOC100199563.
DR   GeneID; 100199563; -.
DR   KEGG; hmg:100199563; -.
DR   OMA; QNEFNPH; -.
DR   OrthoDB; 3060898at2759; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IEA:InterPro.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR024933; TFP11.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329:SF1; TUFTELIN-INTERACTING PROTEIN 11; 1.
DR   PANTHER; PTHR23329; TUFTELIN-INTERACTING PROTEIN 11-RELATED; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 2.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|PIRNR:PIRNR017706};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW   ECO:0000256|PIRNR:PIRNR017706};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017706};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694840};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|PIRNR:PIRNR017706}.
FT   DOMAIN          120..165
FT                   /note="G-patch"
FT                   /evidence="ECO:0000259|PROSITE:PS50174"
SQ   SEQUENCE   788 AA;  90881 MW;  246E168FFDDB4057 CRC64;
     MASDEEFESF EITDFDLESE LYPGQHKKQT KEQAIYGVWA NSDDENDGHM QRKSRKKFEV
     SDYVDPMGFV SGGLFNEKGE ADEKKDDEMN IPVISEERKK GFKSKTVINS KNFGAWEKYT
     TGFGSKMLEK MGYKGKGLGK HGEGITEPIE AFKRGGRAAI GAYGSETKKS REPVYDSEEN
     EEIEIKAEIE KLHQWKKTGE ESGKPKYVYK TAEEVKKSGA TQKLAPLLSY GNNIKVVDMT
     GPETKVLQGY NAIGHQHAKP GEGEKKGIIG DDHKDFDIPE LLYNLNLLVD LAESEIIQID
     RQLRFEKDNV VNLTYEKERL DKVVQNEDIE INNLEHVLRI IDRCKAGFQP DNDEPLTVEG
     LVHCFQTLKD DFYEEYKLYN LDKLVVPLGF PLLARHFSSW QPFSEPTHGI EYVKLWKNVL
     ESEQKNIEFE KTKENRSMSP FERIIWEIWM PHIRTAIGIW QAKNPDPLIS VLEAWVQLIP
     DWVVANILDQ LILPKLQAAV EFWNPLTDPV PIHSWIHPWL PLMGDRLEPL YPPIRHKLSA
     ALTNWYPSDP SAKVILEPWV KVFSRGTMEA FLIRSIYPKL EQCMSEFKIN PHQQILEPFH
     WVMAWKDIIS VHHMVSILEK HLFPKLLQVL RKWLLNSPNY DEVTKWYLGW KSMFGAEYTS
     NPTIKEQFNR ALALMNQAVS GTMQPGAKEN VAYLTSTERR REAEQAFLSE KVQALTSSSI
     PTRFKDLVEQ AAVENGLIFI PLPNRWHEGK TVYSFGKCVI YIDRDVVFYS TEGKWKPLSL
     QELIDYAK
//