ID T2M760_HYDVU Unreviewed; 825 AA.
AC T2M760;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rho GTPase-activating protein 7 {ECO:0000313|EMBL:CDG67901.1};
GN Name=DLC1 {ECO:0000313|EMBL:CDG67901.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG67901.1};
RN [1] {ECO:0000313|EMBL:CDG67901.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG67901.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
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DR EMBL; HAAD01001669; CDG67901.1; -; mRNA.
DR AlphaFoldDB; T2M760; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09538; SAM_DLC1_2-like; 1.
DR CDD; cd08869; START_RhoGAP; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF7; CROSSVEINLESS C, ISOFORM C; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 367..577
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 640..801
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 825 AA; 94491 MW; F41C9572DF7C876E CRC64;
MNSNVIKLQY RMIELEAFEA CCWLKATGFS LFAKMYEEKC FPLEVGAVKI ACNHLDVDSL
QSLIKRLETL NKCAKILQNM EKNQLLNRLD ADQLEFANRQ PLIDIDQNTD SNQAQLESFP
DRFPLKFDED LGIKKDDIDL MNSEFLICAK KQLTEEIKQH LRNSSYDNVM LDSSMDVLID
SSNQIKITLE NLDHHLSEVN TEDEDDNDIN SISSLDELDG VNRNSFQGSF RGHLQVPGMG
STDSGVPSTP IMRSPRKTQY YVKLTRFSYD VERLMSQWFF YSGVRKRRVR WHSFQKSCER
ESMLISNNIM TLSAGQLNVL KKLSLLRLTA LIERYSCNNR TSWHWTVPKI LKKLKVHDYK
DKNIFGVPLL TIAERTGCPL PHSVVLAINY LSRVAKDSIG IFRKSGMKSR IEKLKIQIEL
NPSKIDLDGY SAYDVADMLK QFFRELPEPL LTTKLSDTFI AIHKDIPSEL RLQAMQLAVI
LMPDENRHVL QTILSFLNEV ASYSSVNQMS EANLATCFVP ALFHLCGGGA SKNDKNINNA
PKKMRRSISL QYQKELDDTR AAQECLACMM KCVNFLFCVP DDVMMKCRFT YIEQGEPVPL
EKLGQNGVDP GIDDDYRHHI DTCFSDLLQE TSVNSRSTKW DIHSECDEIT ISYRKVNDGY
PLRVWRAVTE VQASPEEILK RIIKERHLWD DEILEWQVID TLDDCTDVFY YETQSIAPSV
KRDFVILRSW RYNLNGGSCG VVMTSVKHKN EPPTSGVRAT LLAFRCLIEP IGLGRSRLTS
ISRIDYRGTS SRYYNKVVSP RVMSSGVRKI RDSFNCGPDG PETNV
//
