ID T2MA44_HYDVU Unreviewed; 604 AA.
AC T2MA44;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Hepatoma-derived growth factor-related protein 2 {ECO:0000313|EMBL:CDG69148.1};
DE Flags: Fragment;
GN Name=HDGFRP2 {ECO:0000313|EMBL:CDG69148.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG69148.1};
RN [1] {ECO:0000313|EMBL:CDG69148.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG69148.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HDGF family.
CC {ECO:0000256|ARBA:ARBA00005309}.
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DR EMBL; HAAD01002916; CDG69148.1; -; mRNA.
DR AlphaFoldDB; T2MA44; -.
DR EnsemblMetazoa; XM_012698972.1; XP_012554426.1; LOC100213266.
DR EnsemblMetazoa; XM_047277712.1; XP_047133668.1; LOC100213266.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05834; PWWP_HRP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF49; JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A; 1.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT DOMAIN 20..76
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 95..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CDG69148.1"
SQ SEQUENCE 604 AA; 70631 MW; 8B0D74ED787C9718 CRC64;
SIYRIQKNHL KMATTKVFNV GDLVWAKMKG YPHWPARIEE PKPGQVIPKK KYSLFFYGTH
ETAFLGAECL YSYEDFKSKY GKPNKRRGFQ EALEEIVSNP TVVHEQQPEE SESDDESENP
PEAEIEVKKK KEKKEEVSRK RKKPTPAVKK SNKKVRTVKS LEEWSDSDDE ALVIDTSKEK
KKDLVEEEED FEDQTTTEDD SKEDKDDYNP DLDKKKKTKK KKNDTQKPVV NKQSAPKTVK
EKKPRKTSVK KTVKNSDISS VSSVSSSDSS SGDEEIEQLK KRLFKQDFEM SEEQKKKKEE
EKIKEEERKK LAEQSKLHRE KMKKERDIEK KKKINDDNDV NMNEEKSEEK ITEDKIETDI
QTKNDKKLQQ EEKKIDKKQQ EEKKIDKKQQ KEEKKIDKKH QQEEKKIDKE IQKDEKKKLK
EKKSKEKKVK EEKSSKVDEK KEQRKTKDLK TEKKHIKENG KKKENISSEE NKEREQKAIE
AMKRITDDNK DATVAEHLQK LEIELRKNLS VKSTDHIKSL KVLQEISDLN LTASILMKNK
TIVTTLKKIK AYKANQQVSE KATELYSHFK SLFAVAGVST NASVLHHTEP KENKINDKII
TTGL
//
