ID T2MB34_HYDVU Unreviewed; 552 AA.
AC T2MB34;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Neuroepithelial cell-transforming gene 1 protein {ECO:0000313|EMBL:CDG69137.1};
GN Name=NET1 {ECO:0000313|EMBL:CDG69137.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG69137.1};
RN [1] {ECO:0000313|EMBL:CDG69137.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG69137.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; HAAD01002905; CDG69137.1; -; mRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF8; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 198..381
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 456..526
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 63324 MW; E2BEDA5D3D68C28F CRC64;
MSAKPFRFLR RSPRIKKNEE NKVSTSIQDM NLCGAETFGE TVHKPKIKSX RSQNEMNVSE
RSLKRMRSSN LSLASFEGVM PTPMKRLKPS TSSTTSRNLQ EDKENQKAPR KKFSTRVAAL
AKGFSPGSLK KNGSPVQRSS SLNLPNSAXQ NSATQNIPTH FTFKKYKQCT TPTRRRSSKL
WVESLERDVR DWTPQQIRRQ EAIYELCCGE IDLVEDLKLL QEAYFNPVSK LKLLENNDLM
SIFGSIQALI PLHEDLLRRI NEVKNEDGSI YGIGVVLMEW IPTLQPYISY CANQLQTKET
LLDKIRENKQ FADFLQRCQE SPXXRKLDLW SFLDSPRSKL VKYPLLFSNI HRYTPKDDPD
RAILYRSIKQ IEGIIKEADK ITGVSKCIFY KERLTFFDNN ECKSQLDEAQ TLVCHGCLKT
KSGTKVEAFL FDTVFLCSRL ITRNGVKNYH VFLQPIPVVD LEVTDLNDGE HRLGGSFRTT
LTKNSTAKHA IRVSMKDLRK SKSVILQAND QHDKKQWLNS FQSLLKEKNN VEVKSSYSDL
VDRINISCSS DL
//
