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Database: UniProt
Entry: T2MFA1_HYDVU
LinkDB: T2MFA1_HYDVU
Original site: T2MFA1_HYDVU 
ID   T2MFA1_HYDVU            Unreviewed;      1409 AA.
AC   T2MFA1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   22-FEB-2023, entry version 28.
DE   SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:CDG70789.1};
DE   Flags: Fragment;
GN   Name=BRCA2 {ECO:0000313|EMBL:CDG70789.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70789.1};
RN   [1] {ECO:0000313|EMBL:CDG70789.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG70789.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
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DR   EMBL; HAAD01004557; CDG70789.1; -; mRNA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 8.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR   PROSITE; PS50138; BRCA2_REPEAT; 8.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1046..1175
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          1180..1293
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
FT   REGION          156..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          592..735
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          801..903
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CDG70789.1"
FT   NON_TER         1409
FT                   /evidence="ECO:0000313|EMBL:CDG70789.1"
SQ   SEQUENCE   1409 AA;  161060 MW;  5D8B4DE21B975C7C CRC64;
     NVARVLFDVT NVDSLKASDS IISLNTEFDY PYISSSPTLF QDMTKNKNCS LLDLDSNNSL
     YVSMEHDKEN NWISSPTMVF EKEDKYRTNS PGTKYRTNTS VSLTSLTHSI NVEDSDKLNY
     KLKRKFSLNE NLKKDILKID NENCFLSPAV TTKQKKSQKI SYEMKSRSQS TPIEKKKSQE
     SQIKESLIKE SLMNPFYNLN VSNPDIMLSQ DFALTCFNQN DESYIKKLEK HKRNESYLNL
     TNEIFSHSSN DRLLNNSIND EKQFLSPPMI GGFKSNSQFL LSGIWNYSDF YETLTNKDLI
     TDFNESSPIL HAKISAKQSV YVNKTQSFEN ENVTPSSQEL VKGEKYPCSV TIHKNNMAYS
     LDSSIKSICT DKNYIFVPPV IQSCTVVNQT IEQPCLNQTT LLNNLVQNNN NNNNISMQSG
     NSILVNNENL RTKKFSYPKH ENRFQNTPQK ENIGNKKVQK LGLKKSVNYS RNSILPDGFI
     NMDNLTQISA DDINSQKFNN DTMSSSLDQN CPAKFSENIN QDAKKKQVIN KIEVNLLRGL
     ESFQPGFETK VEGSDKSLQE AKKLFQEESN NLVEDTLIED FNGFQTGLGK KVEVSKKSLQ
     EAKKLLQEEN NNIVEDALMK DFNGFQTGLG KKVEVSKKSL QEAKKLFQEE NNNIVEDALM
     KDFNGFQTGL GKKVEVSKKS LQEAEKLFQE ENNNIVEDAL MKDFNGFQTG LGKKVEVSKK
     SLQEAEKLFQ EENNNIVEDA LMKDFNGFQT GLGKKVEISK KSLQEAKKLF HEESNNIVED
     TLIEDFNGFQ TGLGKKVEIS KKSLQEAKKL FQEENKNIVE DALMKDFNGF QTGLGKKVEI
     SKKSLQEAKK LFQEENNNIV EDALMKDFNG FQTGLGKKVE VSKESLQEAK MLFEEENKKL
     LKDKPIKVSM FESFQTDLQA NQEVNVFKKS SRSANELLPE HRNGVESSPV NSHQVKKLAF
     LKEHSTLAYE YDRDAKFILP LPAVITSPDD IFDNCNTTSF DETLKPLKSS FTTPFKMNTT
     PAQNISSFKK ESERKSFCPF QKKRKQGFQT LHSFGIKDQL INLNPSNALM FQFYAGNYFS
     ESVLQSKQAV VGDGVKLHFN EEMMITVNEF KQALLNCSSV DKNLINSTWI ENHYKWIVWK
     LASYERMYPE QNAGICLTPS NVMYQLKYRY DKEVEFSERS CLKCICERDD VSSRRIILCV
     SFCGPDDQTS EDGKFIWVTD GWYEIKASLD YQLSKFVEQG KIDVGTKLCI YGAELIGSEK
     ACPPLEISQS TMLKLSANST RRARWHAKLG YQREKVAFPV PLKSLYTDGG LVGCVKVLIL
     RKYPMQWMEK VGGRCLFRNF FAEEQVKKRY EEERSIKMEQ LYVKLKKELE MKKDKKDVKK
     KKNFNIKLLN CGKDIFEAID GAADPAALE
//
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