ID T2MFA1_HYDVU Unreviewed; 1409 AA.
AC T2MFA1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:CDG70789.1};
DE Flags: Fragment;
GN Name=BRCA2 {ECO:0000313|EMBL:CDG70789.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70789.1};
RN [1] {ECO:0000313|EMBL:CDG70789.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG70789.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HAAD01004557; CDG70789.1; -; mRNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 8.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS50138; BRCA2_REPEAT; 8.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1046..1175
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 1180..1293
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 156..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 592..735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 801..903
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CDG70789.1"
FT NON_TER 1409
FT /evidence="ECO:0000313|EMBL:CDG70789.1"
SQ SEQUENCE 1409 AA; 161060 MW; 5D8B4DE21B975C7C CRC64;
NVARVLFDVT NVDSLKASDS IISLNTEFDY PYISSSPTLF QDMTKNKNCS LLDLDSNNSL
YVSMEHDKEN NWISSPTMVF EKEDKYRTNS PGTKYRTNTS VSLTSLTHSI NVEDSDKLNY
KLKRKFSLNE NLKKDILKID NENCFLSPAV TTKQKKSQKI SYEMKSRSQS TPIEKKKSQE
SQIKESLIKE SLMNPFYNLN VSNPDIMLSQ DFALTCFNQN DESYIKKLEK HKRNESYLNL
TNEIFSHSSN DRLLNNSIND EKQFLSPPMI GGFKSNSQFL LSGIWNYSDF YETLTNKDLI
TDFNESSPIL HAKISAKQSV YVNKTQSFEN ENVTPSSQEL VKGEKYPCSV TIHKNNMAYS
LDSSIKSICT DKNYIFVPPV IQSCTVVNQT IEQPCLNQTT LLNNLVQNNN NNNNISMQSG
NSILVNNENL RTKKFSYPKH ENRFQNTPQK ENIGNKKVQK LGLKKSVNYS RNSILPDGFI
NMDNLTQISA DDINSQKFNN DTMSSSLDQN CPAKFSENIN QDAKKKQVIN KIEVNLLRGL
ESFQPGFETK VEGSDKSLQE AKKLFQEESN NLVEDTLIED FNGFQTGLGK KVEVSKKSLQ
EAKKLLQEEN NNIVEDALMK DFNGFQTGLG KKVEVSKKSL QEAKKLFQEE NNNIVEDALM
KDFNGFQTGL GKKVEVSKKS LQEAEKLFQE ENNNIVEDAL MKDFNGFQTG LGKKVEVSKK
SLQEAEKLFQ EENNNIVEDA LMKDFNGFQT GLGKKVEISK KSLQEAKKLF HEESNNIVED
TLIEDFNGFQ TGLGKKVEIS KKSLQEAKKL FQEENKNIVE DALMKDFNGF QTGLGKKVEI
SKKSLQEAKK LFQEENNNIV EDALMKDFNG FQTGLGKKVE VSKESLQEAK MLFEEENKKL
LKDKPIKVSM FESFQTDLQA NQEVNVFKKS SRSANELLPE HRNGVESSPV NSHQVKKLAF
LKEHSTLAYE YDRDAKFILP LPAVITSPDD IFDNCNTTSF DETLKPLKSS FTTPFKMNTT
PAQNISSFKK ESERKSFCPF QKKRKQGFQT LHSFGIKDQL INLNPSNALM FQFYAGNYFS
ESVLQSKQAV VGDGVKLHFN EEMMITVNEF KQALLNCSSV DKNLINSTWI ENHYKWIVWK
LASYERMYPE QNAGICLTPS NVMYQLKYRY DKEVEFSERS CLKCICERDD VSSRRIILCV
SFCGPDDQTS EDGKFIWVTD GWYEIKASLD YQLSKFVEQG KIDVGTKLCI YGAELIGSEK
ACPPLEISQS TMLKLSANST RRARWHAKLG YQREKVAFPV PLKSLYTDGG LVGCVKVLIL
RKYPMQWMEK VGGRCLFRNF FAEEQVKKRY EEERSIKMEQ LYVKLKKELE MKKDKKDVKK
KKNFNIKLLN CGKDIFEAID GAADPAALE
//