ID T2MIW3_HYDVU Unreviewed; 991 AA.
AC T2MIW3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear export mediator factor NEMF {ECO:0000313|EMBL:CDG71880.1};
DE Flags: Fragment;
GN Name=NEMF {ECO:0000313|EMBL:CDG71880.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG71880.1};
RN [1] {ECO:0000313|EMBL:CDG71880.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG71880.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; HAAD01005648; CDG71880.1; -; mRNA.
DR AlphaFoldDB; T2MIW3; -.
DR EnsemblMetazoa; XM_012705020.1; XP_012560474.1; LOC100199383.
DR EnsemblMetazoa; XM_047277096.1; XP_047133052.1; LOC100199383.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 495..605
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 955..991
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 396..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 277..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 764..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CDG71880.1"
FT NON_TER 991
FT /evidence="ECO:0000313|EMBL:CDG71880.1"
SQ SEQUENCE 991 AA; 113169 MW; FB37EC5E405EFD36 CRC64;
SSSIGLRVAN VYDIDNKTFL VRLTHGEIKS TILVESGNRI HLTEYDWPKS MMPSGFSMKC
RKHLKGRRLA SINQLGVDRI VDMTFGYDEA AYHLIVELYD RGNIVLADFE YNILQLLRVR
TDENADVKFA VREKYPVELA RKEEPLLSIN KLEEIIKSGK STDSLKQVLN PLLIFGPSLL
EHCLLEGGFS PSTKLSQINT SDKQEISKLY SSLQIGDNIL KNISSKEGEG YLIQKKESNA
NAVGEKDLLI YTEFHPFLYH QHKSLPFIHF HSFNKCVDEF FSKLESQKID LKALQQEKAA
LKRLENVRED HEKRIHSLKE TQDKEARRAK LIELNLPLIE RAIIIVNSAI ANQLDWEEIE
DLLKEAKLKG DPVANIIKSL QLKTNQITIS VNNISDEEET ESDEDDLDEG ERKKQNKKSR
KQKKVDIIID LGLTAFGNAR SLHDKRRNAA TKEEKTIQAS KKALKSAEYK TKETLKEVQN
AKIINKTRKT FWFEKFYWFI SSENYLVIGG RDQQQNEILV KRYLKAGDLY VHADLHGASS
VIIKNSTGLD VPPKTLNEAG TMAICYSAAW EARVITSAWW VYHNQVSKTA PSGEYLTTGS
FMIRGKKNFL PPSYLIMGFS VLFKLDESCI SRHVNDRRVK SNDDQENKSI EVEDFESKQL
NNELESESDD SSSKEDIQTE ESMEMKADKM SNLENEELVN EMGNIIDKII KIDTGKQEGD
TGKQEEDTGK IKSDSEDFEN AFPDTNIQLY HVSGGKFELH PEKSGKLNTN TANNTIKSEN
DQITQQQKSL MQQQNRKPRI SAKQRRDLKK KVKQNDNEDN DTVPESSNNI KEKLESTTKN
KVPANKSVAE VKTCDPPKRG AKAKLKKINE KYKDQDEEDR QLFQEIIRSN EPARPPKKTG
KNKIKEKNTK QVQQQKREVK KNTVETIIIE QPEGDQSLTN NIIANDEEPD EEIEKENITI
IDSLTGCPLE DDILLHAIPL CAPYSSLQNY K
//
