ID T2R40_MOUSE Reviewed; 319 AA.
AC Q7TQB8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Taste receptor type 2 member 40;
DE Short=T2R40;
DE Short=mT2R33;
GN Name=Tas2r40; Synonyms=T2r33, Tas2r144, Tas2r44;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAN63043.1};
RN [1] {ECO:0000312|EMBL:AAN63043.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAN63043.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY145468; AAN63043.1; -; Genomic_DNA.
DR EMBL; AC155654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001095; DAA01234.1; -; Genomic_DNA.
DR CCDS; CCDS20062.1; -.
DR RefSeq; NP_001001453.1; NM_001001453.1.
DR AlphaFoldDB; Q7TQB8; -.
DR SMR; Q7TQB8; -.
DR STRING; 10090.ENSMUSP00000067734; -.
DR GlyCosmos; Q7TQB8; 2 sites, No reported glycans.
DR GlyGen; Q7TQB8; 2 sites.
DR PhosphoSitePlus; Q7TQB8; -.
DR PaxDb; 10090-ENSMUSP00000067734; -.
DR Antibodypedia; 32610; 20 antibodies from 11 providers.
DR DNASU; 387515; -.
DR Ensembl; ENSMUST00000063489.4; ENSMUSP00000067734.4; ENSMUSG00000051917.4.
DR GeneID; 387515; -.
DR KEGG; mmu:387515; -.
DR UCSC; uc009bqn.1; mouse.
DR AGR; MGI:2681312; -.
DR CTD; 387515; -.
DR MGI; MGI:2681312; Tas2r144.
DR VEuPathDB; HostDB:ENSMUSG00000051917; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7TQB8; -.
DR OMA; NIFYCLR; -.
DR OrthoDB; 4189279at2759; -.
DR PhylomeDB; Q7TQB8; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387515; 2 hits in 77 CRISPR screens.
DR PRO; PR:Q7TQB8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TQB8; Protein.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR CDD; cd15014; 7tm_TAS2R40; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF143; TASTE RECEPTOR TYPE 2 MEMBER 40; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="Taste receptor type 2 member 40"
FT /id="PRO_0000082314"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 36559 MW; 9508F899390BE4AD CRC64;
MAIITTNSDY FAHRYEVIIP FVVSTICSIV GIIGNGFITV IYGTEWVRSK RLPTGENLML
MLSFSRLLLQ IWMMVEITYS LLFPIIYNHN AMYKLFKAIS VFLNYCNLWF AAWLNVFYCL
KIVNLAHPLF LLMKQKIIGL MPRLLSLSVL VSFSLSSFFS KDILNVYVNT SVPIPSSNST
KMKYIFMINV LSLAFLYYMG IFLPLFMFIM AATLLITSLK RHTLHMENST TGSRDSSMEA
HVGAIKSTSH SLILYIINAL ALFISMSNIL GAYSVWNSLC NIIMTAYPAG QSVHLILRNP
GLRRAWRRFQ HHVHLYLKR
//
