ID T2R42_PANTR Reviewed; 314 AA.
AC Q646B8;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Taste receptor type 2 member 42;
DE Short=T2R42;
DE AltName: Full=T2R55;
GN Name=TAS2R42; Synonyms=TAS2R55;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724879; AAU21101.1; -; Genomic_DNA.
DR RefSeq; XP_016780287.1; XM_016924798.1.
DR AlphaFoldDB; Q646B8; -.
DR SMR; Q646B8; -.
DR STRING; 9598.ENSPTRP00000075248; -.
DR GlyCosmos; Q646B8; 1 site, No reported glycans.
DR Ensembl; ENSPTRT00000008684.5; ENSPTRP00000075248.1; ENSPTRG00000004696.6.
DR GeneID; 107967743; -.
DR KEGG; ptr:107967743; -.
DR CTD; 353164; -.
DR VGNC; VGNC:57795; TAS2R42.
DR GeneTree; ENSGT01100000263477; -.
DR InParanoid; Q646B8; -.
DR OMA; WLRWRMN; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000004696; Expressed in fibroblast.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR CDD; cd15024; 7tm_TAS2R42; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF70; TASTE RECEPTOR TYPE 2 MEMBER 42; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..314
FT /note="Taste receptor type 2 member 42"
FT /id="PRO_0000082347"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 314 AA; 36305 MW; 6DDF89BB91519AC2 CRC64;
MATELDKIFL ILEIAEFIIG MLGNVFIGLV NCSEGIKNQK VFSADFILTC LAISTIGQLF
VILFDSFLVG LASHLYTTYR LGKPVIMLWH MTNHLTTWLA TCLSIFYFFK IAHFPHSLFL
WLRWRMNGMI VMLLILSLFL LIFNSLVLEI FIDISLNIID KSNLTLYLDE SKTVYDKLSI
LKTLLSLTSF IPFSLSLTSL LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSFL
FLFIVHFFSL QVANWIFFML WNNKYIKFAM LALNAFPSCH SFILILGNSK LRQTAVRLLW
HLRNYTKTPN PLPL
//
