ID   T5A9D7_OPHSC            Unreviewed;       672 AA.
AC   T5A9D7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=OCS_05257 {ECO:0000313|EMBL:EQK99030.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQK99030.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQK99030.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQK99030.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; KE653727; EQK99030.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5A9D7; -.
DR   eggNOG; KOG0922; Eukaryota.
DR   HOGENOM; CLU_001832_5_11_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:EQK99030.1};
KW   Helicase {ECO:0000313|EMBL:EQK99030.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000313|EMBL:EQK99030.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT   DOMAIN          31..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          231..406
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   672 AA;  74026 MW;  EDF09123B573751E CRC64;
     MGASDLDSSF IPALHKPAAL LPIAKHRESL LYVIETNPVT IVIGQTGSGK TTQIPQFLER
     AGWCADGKII GITQPRRVAA TTVALRVADE AGCEIGREVG YSIRFEHVTS PATRIKFLTD
     GLLIREALVD PLLSRYSVIM VDEAHERSVS TDILLGLLKK IRRKRPDLRI IISSATLQAD
     KFLGFFSPTG EGQASDKSQD QVGAIVSLEG RTYPIDVLYL ESPAENYVEK AVETVFDIHM
     QEDDGHVLVF LTGREEIDYA VQVVTERAAK AGSRYKAIQP LPLYAGLSTE QQMYVFGKPP
     DGTRKVVFST NIAEASVTID GIAYVLDCGF VKLRAYNPET GIDSLTATPV SKASASQRAG
     RAGRTKPGKC FRLYTEQAHA GLPEANPPGL QRSNLAPAVL QLKALGIDNV VGFDFLSPPP
     SLLMSKALEL LYALGALDEY AKLTRPLGSR MAELAVEPMM AKTLLSAQSF GCLDEILTIA
     AMTSLGGSVW FHDEGEQKRM ESSRRKFAAQ EGDHLTLLNV YNAFVTRGKK ESRFCHENHI
     NYKALTRAAS IRAQLKRYLE RFNMAATDSL LQQPNADMSS TADQIRRCLT AGYFAHAARM
     QPDGTFRNVE GGTVLHAHPS SLMFNRKADW VVFHEVMETG HKTFIRDITK VEKEWLTEYA
     PEYYMLSSAN TL
//