ID T5AGU1_OPHSC Unreviewed; 1968 AA.
AC T5AGU1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000313|EMBL:EQL01814.1};
GN ORFNames=OCS_02473 {ECO:0000313|EMBL:EQL01814.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL01814.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL01814.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL01814.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
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DR EMBL; KE652414; EQL01814.1; -; Genomic_DNA.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_2_0_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT DOMAIN 279..472
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 508..706
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1139..1314
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1344..1538
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 32..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1968 AA; 219745 MW; 78E8674FDF9D51BD CRC64;
MASNNLMAAE AQWREQFAAM KTALANLKLP PAASAADDWD DDDLKGNSSG YSDQDVWDFI
SDDDDDDYSS EFVAVDGADQ ASGQEWFASK CSDVAAKNGL AADVFQAQIL ELLSSGRPDE
ELQVHLTDLV GFDDLEFIIE ILSRKDDIVA ASFVEESQTG EGPRLMTRSQ REEALRRQDA
EHKSSVLAPS HSKEPQYPHV YKSYHAGNTL SLSGKKYALP AGTQHLKFDK YEEHSIPAGR
KGTLGPGERL VKITELDGLC RNTFKGYKTL NRMQSLAFPV AYKTNENMLI CAPTGAGKTD
AAMLTILHTI GQHASPSPVE APAATEFAVD VDDFKIVYVA PMKALAAEVT EKLGKRLAWL
GVKCREYTGD MQLTKSEIIQ TQIIVTTPEK WDVVTRKGTG DTELVQKVRL LIIDEVHMLH
DGRGAVLESL VARTERQVES TQSLIRIVGL SATLPNYVDV ADFLKVNRYA GLFYFDASFR
PVPLEQHFIG VKGKAGSKQS KENMDNVAFD KVKEMLERGH QVMVFVHSRK DTMGTAKMLH
QKAMEQMCSE LFDPSGHPRY EQAARDMNTS RSKEIRELLS KGLGIHHAGM ARADRNLMER
LFGEGVLKVL CCTATLAWGV NLPAAAVVIK GTQVYSAQDG KFVDLGILDV LQIFGRAGRP
QFEDTGIGMI CTTQDKLQHY LTAITEQLPI ESKFSAKLVD NLNAEVALGT VTSIQDAVQW
IGYSYMFVRM QRNPTAYGIE WAEIRDDPTL VQRRRQLAIQ AARTLQQCQM IVFNERTEEL
RSKDIGRIAS QYYILHTSIQ VFNAMMRAQA TEADILKMIS MSGEFDNVQS RDTEAKELTH
LKDNVVPCAV EGGIDTPQTK TNILLQSYIS RQQPEDFALS NDMNYVAQQS GRICRALFML
ALNRRWGHQC LVLLTLSKSI EKRIWPFQHP LHQFDLAKPL LNQLDARENL TVEAMKDMEP
AEIGDLVRNH SAGKSIAKIL NHFPTVHVEA EIAPLNRDVL RIKLHVIPDF TWRDQIHGTS
ESFYVWVENS ETSEIYHHEF FIINRRKLHD DHELNFTIPL SDPLPTQIYV RAVSDRWLGA
ETVTPVSFQH LIRPDTESVY TELLNLQPLP ITALKNPGLE EIYAKRFQFF NPMQTQVFHT
LYHTAANALL GSPTGSGKTV AAELAMWWAF RERPKSKVVY IAPMKALVRE RVKDWGSRLA
RPLGLKLVEL TGDNTPDTRT IKDADIIITT PEKWDGISRS WQTRGYVRQV SLVIIDEIHL
LAGDRGPILE IIVSRMNYIA SSTNNAVRLL GMSTACANAA DLANWLGVKE GLFNFRHSVR
PVPLELYIDG FPEVRGFCPL MQSMNRPTFL AIKNHSPSKP VIVFVASRRQ TRLTAKDLIN
FCGLEEDPRR FLRMDEEDLQ LNLARVKDDA LKEAINFGIG LHHAGLVESD RQLAEELFLN
NKVQILVATS TLAWGVNLPA HLVVVKGTQF YDAKMEGYKD MDLTDVLQML GRAGRPQFDN
SGVARIFTQD SKKDFYKHFL HTGFPVESSL HTVLDNHLCA EVSAETVLTK QDALDYLTWT
FFFRRLHKNP SYYGLQLSAE EHSTMAAQQM ANDYMVEMVN KSLDELAQSR CVEVFPNGDI
ESTPMGKIMS YYYLSHTTIR HLVRHAKAQA SFLDVLSWMC RATEYDELPV RHNEDLVNDA
LSANLPFPGH SFGLPMWDPH VKAFLLLQAH MSRIDLPITD YVGDQTSVLD QAIRIMQASI
DVLTELGHLS SCLQMMRLMQ CIKCARWPTD PPASILPGVE PESAKGDTHI AKMSALAPAQ
VRQLAKSLGV SPSQQPRFAR AVAMLPNVSV SVKEATALSL TVELKRLNAL SDKGARIFAP
KFPKPQTEGW FVVVADVGRD EVVAVKRVGW SATGKNGGPG QGGCPSARAT LKLPDPSPGQ
TRRMDVLVVS DAYVGLEYRV LGVDMAAAAT VDDDVEASKA MMGSSSKA
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