ID T5AK62_OPHSC Unreviewed; 1088 AA.
AC T5AK62;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
GN ORFNames=OCS_01492 {ECO:0000313|EMBL:EQL02801.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02801.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL02801.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02801.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE652265; EQL02801.1; -; Genomic_DNA.
DR AlphaFoldDB; T5AK62; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_0_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT DOMAIN 938..954
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 29..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 118740 MW; 48F7CE125D3FD1CB CRC64;
MAPASRPSGK KQQSLTSFFT PKTVNGLAAS FEKQSRASAS PSDDASSRKR PLDDDAAKAN
ETPERTRKKA KPSPAHAETE DGHVAAPPSP AADAAAPPAR AGRYLYDGAS SAAGPDSDQA
QVDEATKRKN DELHRRFVKK LGHPEALSWR QPEDAAAGQD DGDAQADDDE SPAPAKTKKK
SSKSGKLTPM DLQFLEIKRK HMDTVLIVEV GYKFRFFGED ARIAAKELSI VCIPGKMRYD
EHPSEAHLDR FASASIPVHR LSVHAKRLVA AGHKVGVVRQ IETAALKKAG DNRNTPFVRK
LTSLYTKGTY IDENGELDQQ TEGTPSGGYL LSITETKSKG SGTDEKVDVG ILAVQPATGD
IIYDNFEDGF MRSEMETRLL HISPCEFLIV GDLTKGTDKL VRHLSGSSTN VFGDRSRVRG
TRWQRKSRFG GGGGWTADTA GALRLEDTQG LDSRAIGTLV GGRLAGCLSA MISHLEEYGL
EHIFNLTKYF QHFSTRSHML INGTTLESLE VYRNSTDHSE KGSLFWALDK TLTRFGRRLL
RKWVGRPLLD RDRLEERMGA VQELLDKQST APLDELEKLL SSVKIDLERS LIRIYYGKCT
RPELLSVLRT LQGIATYYSV KTSSSSAAPF AAALLASATG ALPQILDSVV SYLERINLQA
ARKDDKYAFF RDDFQTEDMQ DHQLGIAHVE HELDAHRSDA AAKIKKSAVE YVTVAGIEYL
IEVPNSEIKN VPASWSKISG TKKLSRFHTP EVLRLIAERD QHREALAAAC DKAFKDLLAE
ISADYQPLRD AVTALATIDC LLSLSKVAAQ PGYSRPVVLP SSSEPSISIS QGRHPIAEHT
LEAAYIPFST ALAHPSPLAY LITGPNMGGK SSFVRALALI VLLAQMGSFV PADSLTLTLC
DAIHTRTGAR DNLFAGESTF MVEVSETARI LRSATPRSLV ILDELGRGTS THDGAAIAHA
VLQHIVTETR CLTLFITHYQ NLARVVDGLD GVKNVHMRFR ADDAADGEDI TFLYEVGEGV
AHRSYGLNVA RLARIPKKVL DVAAGKSAEL ELDVRSRRLR GACRTLNDII AGDASEQLPQ
LIASIAQL
//
