ID   T5AKF6_OPHSC            Unreviewed;       550 AA.
AC   T5AKF6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Sulfatase {ECO:0000313|EMBL:EQL02896.1};
GN   ORFNames=OCS_01396 {ECO:0000313|EMBL:EQL02896.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02896.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL02896.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02896.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   EMBL; KE652258; EQL02896.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5AKF6; -.
DR   eggNOG; KOG3867; Eukaryota.
DR   HOGENOM; CLU_006332_9_1_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16032; choline-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017785; Choline-sulfatase.
DR   InterPro; IPR025863; Choline_sulf_C_dom.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   NCBIfam; TIGR03417; chol_sulfatase; 1.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF12411; Choline_sulf_C; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT   DOMAIN          26..368
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   DOMAIN          480..530
FT                   /note="Choline sulfatase enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12411"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  62604 MW;  CF6C7A670D86CC1D CRC64;
     MSPDINSLPR SSAKAHVARA PDGSKPNILY VMADQLAAPQ LRMYNPESQI RTPNLDRLAA
     GSVQFDSAYC PSPLCAPSRM SMITGLLPAK IGAWDNASQV NSEVPTYSHY LRSRGYHTAL
     AGKMHFVGDQ LHGYEQRLTS DIYPGDFGWA VNWDEPDTRL EWYHNASSII QAGPCGRSNQ
     LDYDEEVMFK STQYLWDHVR QGPEKRPFAL TVSLTHPHDP YTITKKYWDL YEDVDIALPK
     VRIPKEKLDT HSQRLLHVSD LWDHDLTDDQ IKRAKRAYYG SVSYVDDCIG KLLETLADAG
     LADDTIVIFS GDHGDMLGER GLWYKMSYFE SSVRVPLLVH YPKWFEPRRV SRNVSTLDLL
     PTICDLIGTK PAPYLPMDGI SMMPHLQGKD GHDTVFAEYA GEGTVRPMMM IRRGPWKYIT
     CPADEPQFYN LARDPLEVDN LARLVKVTPQ TPEQEEAKAM FEQYDAEAKA KWDFDAITAQ
     VLQSQRSRRL VWEALKQGTF TSWDYDPIDD GRTKYIRSTI PLDELERRAR HPFVDSHGSV
     VNKVVRSTRG
//