ID T5CL49_HELPX Unreviewed; 946 AA.
AC T5CL49;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=N404_05745 {ECO:0000313|EMBL:EQL53666.1};
OS Helicobacter pylori FD506.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191281 {ECO:0000313|EMBL:EQL53666.1, ECO:0000313|Proteomes:UP000015964};
RN [1] {ECO:0000313|EMBL:EQL53666.1, ECO:0000313|Proteomes:UP000015964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD506 {ECO:0000313|EMBL:EQL53666.1,
RC ECO:0000313|Proteomes:UP000015964};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL53666.1, ECO:0000313|Proteomes:UP000015964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD506 {ECO:0000313|EMBL:EQL53666.1,
RC ECO:0000313|Proteomes:UP000015964};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-binding oxidoreductase/transferase type
CC 4 family. {ECO:0000256|ARBA:ARBA00008000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL53666.1}.
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DR EMBL; AKHO02000054; EQL53666.1; -; Genomic_DNA.
DR RefSeq; WP_001157731.1; NZ_AKHO02000054.1.
DR AlphaFoldDB; T5CL49; -.
DR PATRIC; fig|1191281.5.peg.683; -.
DR Proteomes; UP000015964; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2190; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}.
FT DOMAIN 37..265
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 536..566
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 946 AA; 106001 MW; 66B3E898E2B6D5FB CRC64;
MQENYDAFFT EASGFLNERV FKDYLRRLAY GIDASCYRYI PKIVAWVKDE EEVQKLCVLA
KKHGVSLTFR AAGSSLSGQA SCDGVLVMAT HFFKDAKILN NATSIQLSCG VIGSNANALL
KPYHKKIGPD PSTINTAMIG GIVANNASGM CCGVEQNSYK TLKSLRVILA DGILLDTANQ
KSVEGFKNTH KDLIEGVLNL RKEILKDKEL HALIKKKYEI KNTTGYSLNA LIDFEDPIEI
ISHLFIGSEG TLGFISSVEL ECVKDYAYKT CALLFYENLE QCAKAAQILA ALKAKQPETI
SSAELMDYAC LKSVKGLEGM PRVILEIKEP NACLLIQSES DDPLILENNM QAILNALSAI
PVVLDSQISS DPTIYQSWWK IRKGIFPIAA SQRRSQSSVI IEDVCFSQEN FVEGTKAIEG
LLKKHDFKDN SIIFGHALSG NLHFVVTPIL ENETERKAFE NLVSDMFLMV SESFGSIKAE
HGTGRMVAPF VEMEWGEKAY KIHKQIKELF DPNGILNPDV IITNDKEIHT KNLKSIHPIE
EYLDMCMECG FCERVCPSKD LSLTPRQRIV IHREIEHLKE RVSQGHNEDQ ILLDELLKES
EYLAHATCAV CHMCSMLCPL GIDTGKIALN YYQKNPKGEK IASKILNNMQ TTTSMARFSL
KSARLVQNLI GSHNLVSLTK GIKKFIKPFP KAFNYMPKNN AYPLENKTHK SEEKVIYFST
CINRSFAPST KMADKRCIQE VFESLCQKAK VSVMYPNGLN ALCCGKAFIN YTDLTKQNNE
KNHEIFLQLS DNGKIPIVLD HSACSTHFFK QMKAYKDLKV YDLSVYIEEV LSPKLKFNPI
NEDIGLYTMC ALKLENKEEL LLNLAKKCTL GEIVIHKETG CCGFAGNKGF FTPELNESAL
SGFQAFYQSY DLKRGFSTSS TCEIGLSEKT HFSWQHIAYL VDACTL
//
