ID T5CVM3_HELPX Unreviewed; 1146 AA.
AC T5CVM3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:EQL66244.1};
GN ORFNames=N408_07840 {ECO:0000313|EMBL:EQL66244.1};
OS Helicobacter pylori FD703.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191285 {ECO:0000313|EMBL:EQL66244.1, ECO:0000313|Proteomes:UP000015969};
RN [1] {ECO:0000313|EMBL:EQL66244.1, ECO:0000313|Proteomes:UP000015969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD703 {ECO:0000313|EMBL:EQL66244.1,
RC ECO:0000313|Proteomes:UP000015969};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL66244.1, ECO:0000313|Proteomes:UP000015969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD703 {ECO:0000313|EMBL:EQL66244.1,
RC ECO:0000313|Proteomes:UP000015969};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL66244.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHS02000061; EQL66244.1; -; Genomic_DNA.
DR AlphaFoldDB; T5CVM3; -.
DR PATRIC; fig|1191285.4.peg.327; -.
DR Proteomes; UP000015969; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EQL66244.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EQL66244.1};
KW Hydrolase {ECO:0000313|EMBL:EQL66244.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EQL66244.1}.
FT DOMAIN 93..345
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 559..752
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 976..1010
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1146 AA; 132095 MW; 1E578B1AD7BDEAF0 CRC64;
MSVKYAQVDP NDPKKEIFIT DEEQSNLARQ KAEELKEAFK DWVYKDYARR THLEQIYNDT
FNNSVLKTYD GSQLELEGFN HHISLRPHQK NAIFRTIQDR AVCLDHQVGA GKTLCAIASC
MEQKRMGLVN KTLIAVPNHL TKQWGDEFYK AYPNANVLVV DSKDTTEKER ELLFNQIANN
NYDAVIIAHT HLELLSNPRG IIEELKEEEL VNAEKNFERQ ELAYKNNPRE TKKPNERAFK
NKLDKIRAKY DAILEKQGSH IDISQMGIDN LIVDEAHLFK NLAFETSMEK IAGLGNQQGS
NRARDLFIKT RYLHQNDKKI MFLTGTPIAN SLSEMYHLQR YLTPGVLKER GLEFFDDWAK
TYGEVVNDFE LDTSAQSYKM VNRFSKFSDV QGLSAMYRAF ADIVSNDDIL KHNPHFVPKV
YGDKPINVVV KRSEEVAQFI GVALENGKYN EGSIIDRMQK CEGKKSKKGQ DNILSCTTDA
RKVALDYRLI DPNAKVEKEF SKSYAMAENI YENYLETHAT KGTQLGFIGL STPKTHSQKV
SLEALDNAHG IENKNPLDEA QELLESLSSY DEKGNLIAPS KKELENELKE KEAKSVNLDE
ELAKGCKFDV YSDVLRHLVQ MGIPQNEIAF IHDAKTEEQK QDLFKKLNRG GVRVLLGSPA
KMGVGTNVQE RLVAMHELDC PWRPDELLQM EGRGIRQGNI LHQNDPENFR MKIYRYATEK
TYDSRMWQII ETKSKGIEQF RNVHKLGLNE LEDFNMGSSN ASEMKAEATG NPLIIEEVKL
RAEIKNEEAK YKAFNKENYF NEENLKNNSS QWDYLKLELK DLETLQSSVM IPTHTEIKLY
DLKNEESKDY ELIKVKEVEP LKENASMSEE LTHKKLKEQN KQIAEQNKEK LDAIKKQFAS
NLNDLFFNEE RDCKLLEYKG FVVNAYKTKY QVEFSLSPKD NPNIAYSPSN MVYKNDTANM
FSSYNFCGEI KFDGFLKRLD NAITKLPEKI KELENSIETT QENIAKYTRL VDQKPSYPRL
EYLQALKGDH KTLIDDLAKM SKDRDYKPVF NPKSKEVLEK MNAEKRASLE NESKTITEIE
NSNKEQEIKG NTKSDDEVKQ HIEQVIEKEI GKGAEIISSK EVAITNNVDY YENEEELETT
QSRSRR
//
