ID T5D703_HELPX Unreviewed; 401 AA.
AC T5D703;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
DE Flags: Fragment;
GN Name=fumC {ECO:0000313|EMBL:EQL66601.1};
GN ORFNames=N408_05840 {ECO:0000313|EMBL:EQL66601.1};
OS Helicobacter pylori FD703.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191285 {ECO:0000313|EMBL:EQL66601.1, ECO:0000313|Proteomes:UP000015969};
RN [1] {ECO:0000313|EMBL:EQL66601.1, ECO:0000313|Proteomes:UP000015969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD703 {ECO:0000313|EMBL:EQL66601.1,
RC ECO:0000313|Proteomes:UP000015969};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL66601.1, ECO:0000313|Proteomes:UP000015969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD703 {ECO:0000313|EMBL:EQL66601.1,
RC ECO:0000313|Proteomes:UP000015969};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL66601.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHS02000042; EQL66601.1; -; Genomic_DNA.
DR RefSeq; WP_000597036.1; NZ_AKHS02000042.1.
DR AlphaFoldDB; T5D703; -.
DR PATRIC; fig|1191285.4.peg.720; -.
DR Proteomes; UP000015969; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EQL66601.1}.
FT DOMAIN 5..279
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 345..397
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EQL66601.1"
SQ SEQUENCE 401 AA; 43818 MW; C1A2E6DEE09F3ACD CRC64;
KLSLEKSQAI IKACDCILKG ELCGEFPLAI WQTGSGTQTN MNLNEVIANK ATEILGGNFR
EKKLIHPNDD VNMSQSSNDT FPTAMHIVSV LEITHKLLPS LENLLKTFKD KSQQFKEIVK
IGRTHLQDAT PLTLGQEFSG YASMLEHSKQ QILESLEHLR ELAIGGTAVG TGLNAHKELS
EKVAEELSQF SGVKFISAPN KFHALTSHDA IAYAHGAFKA LAANLMKIAN DIRWLASGPR
CGLGELNIPE NEPGSSIMPG KVNPTQCEAM TMVAVQVMGN DTAIGIAASQ GNFELNVFKP
VIIYNFLQSL RLLSDSMESF NIHCASGIEP NKEKIDYYLH HSLMLVTALN PHVGYENAAK
IAKNAHKKGI SLKESTVELN LLSAEDFDKF VVPEKMIGPK A
//
