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Database: UniProt
Entry: TAF8_DROME
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ID   TAF8_DROME              Reviewed;         328 AA.
AC   Q9VWY6; O18398; Q8SYE2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=Transcription initiation factor TFIID subunit 8;
DE   AltName: Full=Protein prodos;
GN   Name=Taf8 {ECO:0000312|EMBL:AAF48800.1};
GN   Synonyms=pds {ECO:0000303|PubMed:11134347},
GN   prod {ECO:0000312|EMBL:CAA75667.1}; ORFNames=CG7128;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000312|EMBL:CAA75667.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Canton-S {ECO:0000312|EMBL:CAA75667.1};
RA   Ortuno-Sahagun D.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAF48800.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAF48800.1}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000312|EMBL:AAL49226.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAL49226.1};
RC   TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5] {ECO:0000305}
RP   FUNCTION, AND INTERACTION WITH TAF10B.
RX   PubMed=11134347; DOI=10.1128/mcb.21.2.614-623.2001;
RA   Hernandez-Hernandez A., Ferrus A.;
RT   "Prodos is a conserved transcriptional regulator that interacts with
RT   dTAF(II)16 in Drosophila melanogaster.";
RL   Mol. Cell. Biol. 21:614-623(2001).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-245 AND SER-255, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- FUNCTION: TFIID is a multimeric protein complex that plays a central
CC       role in mediating promoter responses to various activators and
CC       repressors. {ECO:0000269|PubMed:11134347}.
CC   -!- SUBUNIT: Belongs to the TFIID complex which is composed of TATA binding
CC       protein (Tbp) and a number of TBP-associated factors (TAFs). Histone
CC       fold interacts with N-terminus of Taf10b.
CC       {ECO:0000269|PubMed:11134347}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TAF8 family. {ECO:0000255}.
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DR   EMBL; Y15513; CAA75667.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAF48800.1; -; Genomic_DNA.
DR   EMBL; AY071604; AAL49226.1; -; mRNA.
DR   RefSeq; NP_523397.1; NM_078673.4.
DR   AlphaFoldDB; Q9VWY6; -.
DR   SMR; Q9VWY6; -.
DR   BioGRID; 59112; 8.
DR   IntAct; Q9VWY6; 6.
DR   STRING; 7227.FBpp0074288; -.
DR   iPTMnet; Q9VWY6; -.
DR   PaxDb; 7227-FBpp0074288; -.
DR   DNASU; 32792; -.
DR   EnsemblMetazoa; FBtr0074514; FBpp0074288; FBgn0022724.
DR   GeneID; 32792; -.
DR   KEGG; dme:Dmel_CG7128; -.
DR   AGR; FB:FBgn0022724; -.
DR   CTD; 129685; -.
DR   FlyBase; FBgn0022724; Taf8.
DR   VEuPathDB; VectorBase:FBgn0022724; -.
DR   eggNOG; KOG4336; Eukaryota.
DR   GeneTree; ENSGT00390000017567; -.
DR   HOGENOM; CLU_070829_0_0_1; -.
DR   InParanoid; Q9VWY6; -.
DR   OMA; SAHNYCE; -.
DR   OrthoDB; 5483295at2759; -.
DR   PhylomeDB; Q9VWY6; -.
DR   Reactome; R-DME-6807505; RNA polymerase II transcribes snRNA genes.
DR   BioGRID-ORCS; 32792; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 32792; -.
DR   PRO; PR:Q9VWY6; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0022724; Expressed in cleaving embryo and 23 other cell types or tissues.
DR   ExpressionAtlas; Q9VWY6; baseline and differential.
DR   Genevisible; Q9VWY6; DM.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IDA:UniProtKB.
DR   CDD; cd08049; TAF8; 1.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR006565; BTP.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR037818; TAF8.
DR   InterPro; IPR019473; TFIID_su8_C.
DR   PANTHER; PTHR46469; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8; 1.
DR   PANTHER; PTHR46469:SF1; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8; 1.
DR   Pfam; PF07524; Bromo_TP; 1.
DR   Pfam; PF10406; TAF8_C; 1.
DR   SMART; SM00576; BTP; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..328
FT                   /note="Transcription initiation factor TFIID subunit 8"
FT                   /id="PRO_0000118886"
FT   DOMAIN          16..83
FT                   /note="Histone-fold"
FT                   /evidence="ECO:0000255"
FT   REGION          229..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..265
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         236
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         245
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   CONFLICT        164
FT                   /note="Q -> H (in Ref. 1; CAA75667)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        250
FT                   /note="M -> I (in Ref. 4; AAL49226)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   328 AA;  36649 MW;  A3CD62A4BC2EDC7C CRC64;
     MEKVEAVTVS NVDPYRRILN KVVSQLLLDK GAGQASNHSL ETLTQMLQAL IWEIGNSAHN
     YCELSGRTMP TVGDVSLALI NMGISISNLD PYMRKETHVP IPLPPQQTQQ RPLSLLQAGI
     KAPHPHYVPS YFPPMPDPHA YIRTPTHKQP VTEYEAIREK AACQKRDIEK ALTKFLCKTT
     ETNNLFPTED NMFPLIACKP AFPPYAAALN PTDQVFDFEE LEYHYLVANR TEDEPSKDDG
     EEGDSENEEM DGDKSKEEKP ELDIKPNSNT NKAILENPNI DNPYLRAATL PKRSKNCPTP
     GTMPSRSLAT TAPTIRTPST LEITKTNL
//
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