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Database: UniProt
Entry: TAL2_YEAST
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ID   TAL2_YEAST              Reviewed;         333 AA.
AC   P53228; D6VUI1; Q6Q5P8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 174.
DE   RecName: Full=Transaldolase NQM1;
DE            EC=2.2.1.2;
DE   AltName: Full=Non-quiescent mutant protein 1;
GN   Name=NQM1; OrderedLocusNames=YGR043C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-78.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9290212;
RX   DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA   Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT   "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT   chromosome VII.";
RL   Yeast 13:1077-1090(1997).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SUBUNIT, AND CATALYTIC ACTIVITY.
RX   PubMed=18831051; DOI=10.1002/prot.22237;
RA   Huang H., Rong H., Li X., Tong S., Zhu Z., Niu L., Teng M.;
RT   "The crystal structure and identification of NQM1/YGR043C, a transaldolase
RT   from Saccharomyces cerevisiae.";
RL   Proteins 73:1076-1081(2008).
CC   -!- FUNCTION: Transaldolase is important for the balance of metabolites in
CC       the pentose-phosphate pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate =
CC         beta-D-fructose 6-phosphate + D-erythrose 4-phosphate;
CC         Xref=Rhea:RHEA:17053, ChEBI:CHEBI:16897, ChEBI:CHEBI:57483,
CC         ChEBI:CHEBI:57634, ChEBI:CHEBI:59776; EC=2.2.1.2;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10019,
CC         ECO:0000269|PubMed:18831051};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-
CC       ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage):
CC       step 2/3.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:18831051}.
CC   -!- MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the transaldolase family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z72828; CAA97042.1; -; Genomic_DNA.
DR   EMBL; AY557832; AAS56158.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08142.1; -; Genomic_DNA.
DR   PIR; S64337; S64337.
DR   RefSeq; NP_011557.1; NM_001181172.1.
DR   PDB; 3CQ0; X-ray; 1.90 A; A/B=1-333.
DR   PDBsum; 3CQ0; -.
DR   AlphaFoldDB; P53228; -.
DR   SMR; P53228; -.
DR   BioGRID; 33290; 61.
DR   MINT; P53228; -.
DR   STRING; 4932.YGR043C; -.
DR   iPTMnet; P53228; -.
DR   MaxQB; P53228; -.
DR   PaxDb; 4932-YGR043C; -.
DR   PeptideAtlas; P53228; -.
DR   EnsemblFungi; YGR043C_mRNA; YGR043C; YGR043C.
DR   GeneID; 852934; -.
DR   KEGG; sce:YGR043C; -.
DR   AGR; SGD:S000003275; -.
DR   SGD; S000003275; NQM1.
DR   VEuPathDB; FungiDB:YGR043C; -.
DR   eggNOG; KOG2772; Eukaryota.
DR   GeneTree; ENSGT00390000017361; -.
DR   HOGENOM; CLU_047470_0_1_1; -.
DR   InParanoid; P53228; -.
DR   OMA; IVRFGCE; -.
DR   OrthoDB; 1972468at2759; -.
DR   BioCyc; YEAST:YGR043C-MONOMER; -.
DR   BRENDA; 2.2.1.2; 984.
DR   UniPathway; UPA00115; UER00414.
DR   BioGRID-ORCS; 852934; 0 hits in 10 CRISPR screens.
DR   EvolutionaryTrace; P53228; -.
DR   PRO; PR:P53228; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P53228; Protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0004801; F:transaldolase activity; IDA:SGD.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central.
DR   CDD; cd00957; Transaldolase_TalAB; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001585; TAL/FSA.
DR   InterPro; IPR004730; Transaldolase_1.
DR   InterPro; IPR018225; Transaldolase_AS.
DR   NCBIfam; TIGR00874; talAB; 1.
DR   PANTHER; PTHR10683; TRANSALDOLASE; 1.
DR   PANTHER; PTHR10683:SF18; TRANSALDOLASE; 1.
DR   Pfam; PF00923; TAL_FSA; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS01054; TRANSALDOLASE_1; 1.
DR   PROSITE; PS00958; TRANSALDOLASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Pentose shunt; Reference proteome; Schiff base; Transferase.
FT   CHAIN           1..333
FT                   /note="Transaldolase NQM1"
FT                   /id="PRO_0000173575"
FT   ACT_SITE        144
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10019"
FT   CONFLICT        290
FT                   /note="F -> S (in Ref. 3; AAS56158)"
FT                   /evidence="ECO:0000305"
FT   HELIX           15..21
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          25..29
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           33..35
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           37..39
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          42..45
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           48..55
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           58..60
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           61..74
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           78..98
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          105..108
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           111..113
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           117..133
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           138..140
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          141..146
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           149..162
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          166..171
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           174..182
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          186..192
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           193..201
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   TURN            209..211
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           213..228
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          233..237
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           242..248
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   STRAND          251..257
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           258..266
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           277..280
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           281..283
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           294..303
FT                   /evidence="ECO:0007829|PDB:3CQ0"
FT   HELIX           305..333
FT                   /evidence="ECO:0007829|PDB:3CQ0"
SQ   SEQUENCE   333 AA;  37254 MW;  6492030A7DA3D343 CRC64;
     MSEPSEKKQK VATSSLEQLK KAGTHVVADS GDFEAISKYE PQDSTTNPSL ILAASKLEKY
     ARFIDAAVEY GRKHGKTDHE KIENAMDKIL VEFGTQILKV VPGRVSTEVD ARLSFDKKAT
     VKKALHIIKL YKDAGVPKER VLIKIASTWE GIQAARELEV KHGIHCNMTL LFSFTQAVAC
     AEANVTLISP FVGRIMDFYK ALSGKDYTAE TDPGVLSVKK IYSYYKRHGY ATEVMAASFR
     NLDELKALAG IDNMTLPLNL LEQLYESTDP IENKLNSESA KEEGVEKVSF INDEPHFRYV
     LNEDQMATEK LSDGIRKFSA DIEALYKLVE EKM
//
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