ID THNS1_MACFA Reviewed; 743 AA.
AC Q9BH05;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Threonine synthase-like 1;
DE Short=TSH1;
GN Name=THNSL1; ORFNames=QflA-10072;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Frontal cortex;
RX PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Prediction of unidentified human genes on the basis of sequence similarity
RT to novel cDNAs from cynomolgus monkey brain.";
RL Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR EMBL; AB055251; BAB21875.1; -; mRNA.
DR AlphaFoldDB; Q9BH05; -.
DR SMR; Q9BH05; -.
DR Ensembl; ENSMFAT00000077670.1; ENSMFAP00000051426.1; ENSMFAG00000064275.1.
DR Ensembl; ENSMFAT00000085006.1; ENSMFAP00000061334.1; ENSMFAG00000064275.1.
DR GeneTree; ENSGT00940000161144; -.
DR OrthoDB; 5309433at2759; -.
DR Proteomes; UP000233100; Chromosome 9.
DR CDD; cd00464; SK; 1.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..743
FT /note="Threonine synthase-like 1"
FT /id="PRO_0000185647"
FT MOD_RES 281
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8IYQ7"
FT MOD_RES 351
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 743 AA; 83189 MW; F4C4773989F72824 CRC64;
MFHFNRCQHL KKITQKCFSS IHVKTDKHAQ QFLSRTFALA ELRKSWYSTH SLVGDKNIIL
MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS EKLQDVGNEQ FLEEEGKAVL
NFSASGSVIS LTGSNPMHDA SMWHLKKNGV IVYLDVPLLD LIHRLKLMKI DRIVGRNSGT
SMKDLLKFRR QYYKKWYDAR VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPK
DCEQKVSAKF FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYIE RAQILLERCI
HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF KDLSLQLMPH
IFAHCIPPSC NYMILVATSG DTGSAVLNGF SRLNKNDKQR IAVVTFFPEN GVSDFQKAQI
IGSQRENGWA VGVESDFDFC QTAIKRIFND SDFTGFLTVE YGTILSSANS INWGRLLPQV
VYHASAYLDL VSQGFISFGS PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNRVL
TDFIKTGHYD LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNQLESQHHF
QIEKVLVEKL QQDFVADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA DRVQDKTCPV
IVSSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA LPPLHEALLE RTKQQEKMEY
QVCAADMNVL KSHVEKLIQN QFI
//
