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Database: UniProt
Entry: TMA64_YEAST
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ID   TMA64_YEAST             Reviewed;         565 AA.
AC   Q04600; D6VSA2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-SEP-2017, entry version 116.
DE   RecName: Full=Translation machinery-associated protein 64;
GN   Name=TMA64; OrderedLocusNames=YDR117C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
RA   Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
RA   Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
RA   Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
RA   Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
RA   Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
RA   Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
RA   Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
RA   Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
RA   Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
RA   Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
RA   Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
RA   Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
RA   Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
RA   Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
RA   Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
RA   Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
RA   Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
RA   Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
RA   Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
RA   Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
RA   Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DOMAINS.
RX   PubMed=10093218; DOI=10.1007/PL00006472;
RA   Aravind L., Koonin E.V.;
RT   "Novel predicted RNA-binding domains associated with the translation
RT   machinery.";
RL   J. Mol. Evol. 48:291-302(1999).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX   PubMed=16702403; DOI=10.1101/gad.1422006;
RA   Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.;
RT   "Systematic identification and functional screens of uncharacterized
RT   proteins associated with eukaryotic ribosomal complexes.";
RL   Genes Dev. 20:1294-1307(2006).
CC   -!- SUBUNIT: Interacts with the 40S ribosomal subunit.
CC       {ECO:0000269|PubMed:16702403}.
CC   -!- DOMAIN: The PUA and the SUI1 domains may be involved in RNA
CC       binding. {ECO:0000269|PubMed:10093218}.
CC   -!- MISCELLANEOUS: Present with 3870 molecules/cell in log phase SD
CC       medium. {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the eIF2D family. {ECO:0000305}.
DR   EMBL; Z48758; CAA88670.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11962.1; -; Genomic_DNA.
DR   PIR; S52682; S52682.
DR   RefSeq; NP_010402.3; NM_001180425.3.
DR   ProteinModelPortal; Q04600; -.
DR   BioGrid; 32173; 234.
DR   IntAct; Q04600; 14.
DR   MINT; MINT-2492923; -.
DR   STRING; 4932.YDR117C; -.
DR   iPTMnet; Q04600; -.
DR   MaxQB; Q04600; -.
DR   PRIDE; Q04600; -.
DR   EnsemblFungi; YDR117C; YDR117C; YDR117C.
DR   GeneID; 851695; -.
DR   KEGG; sce:YDR117C; -.
DR   EuPathDB; FungiDB:YDR117C; -.
DR   SGD; S000002524; TMA64.
DR   GeneTree; ENSGT00550000074865; -.
DR   HOGENOM; HOG000248777; -.
DR   InParanoid; Q04600; -.
DR   KO; K15027; -.
DR   OMA; SASIQPR; -.
DR   OrthoDB; EOG092C46NJ; -.
DR   BioCyc; YEAST:G3O-29717-MONOMER; -.
DR   PRO; PR:Q04600; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   GO; GO:0003723; F:RNA binding; IDA:SGD.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0002192; P:IRES-dependent translational initiation of linear mRNA; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IPI:SGD.
DR   Gene3D; 1.10.245.10; -; 1.
DR   Gene3D; 2.30.130.10; -; 1.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR003121; SWIB_MDM2_domain.
DR   Pfam; PF01253; SUI1; 1.
DR   Pfam; PF02201; SWIB; 1.
DR   SUPFAM; SSF47592; SSF47592; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Reference proteome.
FT   CHAIN         1    565       Translation machinery-associated protein
FT                                64.
FT                                /FTId=PRO_0000244640.
FT   DOMAIN       89    170       PUA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00161}.
FT   DOMAIN      363    446       SWIB.
FT   DOMAIN      475    547       SUI1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00200}.
FT   COMPBIAS    558    565       Poly-Lys.
SQ   SEQUENCE   565 AA;  63992 MW;  2ED921EFABEF3739 CRC64;
     MFKKEPHIKA LSNLKNSERK KLLQTFQKQT NNEEYSFRTS TIKQTNFNGQ KSVGTVYTDE
     NNTPILFKEK HKEQLFPTVY SCWEYPALLP IVLTHGFVIE EHLFNGANLM ISGSIPPFDP
     RCKIGTLCGI ASKQAPETVL AIGIVELDLP SFDKVIGETG VAVKIIHHFN DGLSKVFKMK
     LEPPFVLSTQ SKDNNISSKQ IESSEQIKAV EKEQEDVKEA SVDVEEIAEV LDHFTVSDVD
     YFITRALYYT LTQDKGLELP ISASNFISNH IMRNLPPIDH NEVNVKKTSW KKSAKFLKHF
     EKEGFLKLKG KGDDLTIVGK NTDKDELKNF VPYKLGCSKS ATESRESTTS KEKTSGMMYS
     LTLYKPFNLA KDLLKEVNLA SHTYYTSQDI RSAVSQYISV KNLADTKDKG KVIMDDLLFD
     MVNKKKKVLN ASRIIARGEI LHPLLTNNFT EFYQIFKSDD TLLFKAPMKG SLPHIKIITE
     MKIGRKVITR VSNFEVFQVD PESLAADLRK ICSGSTTISE SQTFKCAEVQ VQGPHGQSII
     DHLNKLGIPS KWIDFENKLK KKKRK
//
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