ID TNC18_MOUSE Reviewed; 2878 AA.
AC Q80WC3; Q1LZJ7; Q69Z86;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 24-JAN-2024, entry version 110.
DE RecName: Full=Trinucleotide repeat-containing gene 18 protein;
DE AltName: Full=Zinc finger protein 469;
GN Name=Tnrc18; Synonyms=Kiaa1856, Zfp469;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-2878 (ISOFORM 3).
RC TISSUE=Embryonic tail;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199 AND SER-540, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80WC3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80WC3-2; Sequence=VSP_033133, VSP_033134;
CC Name=3;
CC IsoId=Q80WC3-3; Sequence=VSP_033130, VSP_033131, VSP_033132;
CC -!- MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.
CC -!- CAUTION: Gene prediction inferred by homology with the human sequence.
CC First thought to be the product of 2 distinct genes Tnrc18 and Zfp469.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI15864.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC175314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC184111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC175490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC182436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC175488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC144818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049818; AAH49818.1; -; mRNA.
DR EMBL; BC115863; AAI15864.1; ALT_INIT; mRNA.
DR EMBL; AK173280; BAD32558.1; -; mRNA.
DR RefSeq; NP_001116202.2; NM_001122730.2.
DR RefSeq; NP_839973.1; NM_178242.2.
DR SMR; Q80WC3; -.
DR BioGRID; 231181; 8.
DR STRING; 10090.ENSMUSP00000114769; -.
DR iPTMnet; Q80WC3; -.
DR PhosphoSitePlus; Q80WC3; -.
DR jPOST; Q80WC3; -.
DR MaxQB; Q80WC3; -.
DR PaxDb; 10090-ENSMUSP00000114769; -.
DR PeptideAtlas; Q80WC3; -.
DR ProteomicsDB; 259594; -. [Q80WC3-1]
DR ProteomicsDB; 259595; -. [Q80WC3-2]
DR ProteomicsDB; 259596; -. [Q80WC3-3]
DR Pumba; Q80WC3; -.
DR DNASU; 231861; -.
DR GeneID; 231861; -.
DR KEGG; mmu:231861; -.
DR UCSC; uc033inn.1; mouse. [Q80WC3-1]
DR AGR; MGI:3648294; -.
DR CTD; 84629; -.
DR MGI; MGI:3648294; Tnrc18.
DR eggNOG; KOG1886; Eukaryota.
DR InParanoid; Q80WC3; -.
DR OrthoDB; 5401688at2759; -.
DR PhylomeDB; Q80WC3; -.
DR BioGRID-ORCS; 231861; 4 hits in 47 CRISPR screens.
DR ChiTaRS; Tnrc18; mouse.
DR PRO; PR:Q80WC3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80WC3; Protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR CDD; cd04714; BAH_BAHCC1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR048924; BAHCC1-like_Tudor.
DR PANTHER; PTHR12505; PHD FINGER TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR12505:SF21; TRINUCLEOTIDE REPEAT-CONTAINING GENE 18 PROTEIN; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF21744; BAHCC1-like_Tudor; 1.
DR SMART; SM00439; BAH; 1.
DR PROSITE; PS51038; BAH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..2878
FT /note="Trinucleotide repeat-containing gene 18 protein"
FT /id="PRO_0000330826"
FT DOMAIN 2727..2872
FT /note="BAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1825..2040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2052..2080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1410..1442
FT /evidence="ECO:0000255"
FT COMPBIAS 117..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..972
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..992
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1775
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1825..1850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1921..1936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1967..1988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2332..2348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2369..2415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2486..2520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2522..2536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2543..2582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2603..2627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2628..2644
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2656..2681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 199
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1053
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 1062
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 1469
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 1789
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 1795
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 2077
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT MOD_RES 2681
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT CROSSLNK 549
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O15417"
FT VAR_SEQ 1..629
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_033130"
FT VAR_SEQ 1440..1482
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_033131"
FT VAR_SEQ 1566..2710
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_033132"
FT VAR_SEQ 1754..1755
FT /note="DD -> GY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033133"
FT VAR_SEQ 1756..2878
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033134"
FT CONFLICT 670
FT /note="L -> Q (in Ref. 2; AAI15864)"
FT /evidence="ECO:0000305"
FT CONFLICT 860
FT /note="V -> VQ (in Ref. 2; AAI15864 and 3; BAD32558)"
FT /evidence="ECO:0000305"
FT CONFLICT 965
FT /note="P -> A (in Ref. 2; AAI15864)"
FT /evidence="ECO:0000305"
FT CONFLICT 1564
FT /note="S -> F (in Ref. 3; BAD32558)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2878 AA; 307635 MW; BE28353487DC666B CRC64;
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPS SGLPGPPPPG KYMAGLNLHP
HPGFSHLPSG LYPSYLHLNH LDPPSSGSPL LSQLGQPSIF DTQKDGFYLP APGTLHAHTP
SSRTPSGHSS GGPAKGSSRE GTGKDRAGRG GDPPPLFGKK DPRAREEVSG PRGVVDLTQE
ARAEGRQDRG SSRLAERLSP FLAEVKAKGA LQPSALSLCN GVVDAGLVAE LGRGGAKEVA
RQEENARLLR RAEALLPAAR PCGSPLPPPP PLPPKGPPAP PSSTPAGVYT VFREPGREHR
VVAPTFVPSV EAFDERVGPI QIASQARDVR AREREPGRPG VLQGPPGSPR LERPEVLREK
SSVIRSLKRP PPSDGPPAAR SSRSSPDARA YLPPKELLKP EADPRPCERA PRGPSASAAQ
QAAKLFGLEP SRPPGPEHKW KPFELGNFAT TQMAVLAAQH HHASRAEEEA AVATASKKAY
LDPGGAMPRA SATCGRPGAD LHSAAHGPGE ASAMQSLIKY SGSFAREAVA VRPGGCGKKS
PFGGLGTMKP EPTPTSAGPP RAQARLTHPG VPTAGGGRQL KRDPERPESA KAFGREGSGA
QGEAEVRHPP VGIAVAVARQ KDSGSSSRLG PGLGDQERTL SLNNVKGHGR TDDECDRARH
REDRLLGTRL DRDQEKLLRE SKELADLARL HPTSCAPNGL NPNLMVTGGP TLAGSGRWSA
DPAAHLATNP WLPRSGSTSM WLAGHPYGLG PPSLHQGMAP AFPPGLGGSL PSAYQFVRDP
QSGQLVVIPS DHLPHFAELM ERAAVPPLWP ALYPPGRSPL HHAQQLQLFS QQHFLRQQEL
LYLQQQAAQA LELQRSAQLV ERLKAQEHRT EMEEKISKRS LETTGKAGLS AAGPGLLPRK
SAGLANGPAG SHGKAVSPPP SPRASPVTSL KAKVIQKVED VSKPPAYTYP ATPSSHPSSP
PPASPPPTPG LTRKEEAPEN VVEKKDLELE KETPSPFQAL FTDIPPRYPF QALPPHYGRP
YPFLLQPAAA SDADGLAPDV PLPADGPERL ALSPEDKPIC LSPSKIPEPP RDSPEEEQLA
DREVKAEVED IEEGPTELPP LESPLALPVP ETMVAVSPAG GCGGSPLEAQ ALSTAGPGCR
EPSEVSDFAQ VAEPQIELPS KTEHRMTALE LGTQLTPEPL VETKEEPVEV PLDVPMEEPT
TEAGPEDSLP QPSLTEPQPS LELSDCDLPV PEGQCLNLEA QEAVPAPAST CYLEETHSES
LLPGLDDPLA GMNALAAAAE LPQARPLPSL GPGVPAGEKL DTAPSLVLEH SFLQGITLLS
EIAELELDRR GQEAADPEPN LVVRPSLESL LAASSHMLKE VLESPFSDPL KNLRLPRELN
SNKKYSWMQK KEERMFAMKS SLEDMDALEL DFRMRLAEVQ RRYKEKQREL VKLQRRRDSG
DRHEDAHRSL ARRGPGRPRK RTHTLSALSP PCKRKSHSSS GKGLSSKSLL TSDDYDLGAG
IRKRHKGPEE EQEALMGMGK ARSRNQSWDD HDSSSDFMSQ LKIKKKKMAS DQEQLASKLD
RALSLTKQDK LKSPFKFSDG PGGKPKTGGG CGRFLTQYDS LLGKDRKALA KGLGLSLKPS
REGKHKRASK ARKMEGGFQA RGQPKSVHSP FASEVSSQSY NTDSDEDEDF LKNEWSAQGP
SSSKLTSSLL CGMVPKNSKP ATGPKLTKRG LAGPRTLKPK VVTSRKQSFC LLLREAEARS
SFSDSSEEDS FDQDDSSEEE EEELEEEEED EEEEGIGSYR LGAGEQALSP SLEESGLGLL
ARFAASALPS PVVGPPLSVV QLEAEQKARK KEERQSLLGT EFEYTDSESE VKVPKQSAAG
LLRTKKGVGE PGQSLAAPGP GSRASGPSSP DKAKLVSEKG RKARKIRGPK EPGFEAGPEA
SDDDLWTRRR SERIFLHDAS AAVQATSNTA PATKPSRCGR GGAPSPRKDT GRAKDRKDPR
KKKRGKEAGS AATLPPPRVS TLPDSRAPHP GALATAKRSK AKARGKEAKK ENRGKGGAVS
KLMECMAAEE DFEANQDSSF SEDEHLPRGG ATERPLTPAP RSCIIDKEEL KDGLRVLIPL
DDKLLYAGHV QTVHSPDIYR VVVEGERGNR PHIYCLEQLL QEAIIDVRPA STRFLPQGTR
IAAYWSQQYR CLYPGTVVRG LLDLEDDGDL ITVEFDDGDT GRIPLSHIRL LPPDYKIQCA
EPSPALLVPS AKRRSRKTSK DTGEVKEGAA TGPQEATGGK ARGRGRKPST KAKADRAVVL
EEGAATNEVP SAPLALEPIS TPNSKKSTPE PVDKRARAPK ARSISAQPSP VPPTFSSCPA
PEPFGELPTP ATAPLVTMPV TMPATRPKPK KARAAEGSGA KGPRRPGEDD ELLVKLDHEG
VMSPKSKKAK EALLLREDPG PGGWPESTGL LSLGSYSPAV GSSEPKATWP KGLDGDLTQE
PGPGLPLEDP GNSKNPDKAQ AEQDGAEESE TTSSSSSSSS SSSSSSSSSS SSSSSSSGSE
TEGEEDAEKN REDGRGAGGR TCSAASSRAS SPASSSSSSS SSSSSSSSSS SSSSSSSTTD
EDSSCSSDEE AAPAPAAGPS TQPALPTKVS KPPSKARSSA HSPGKKAPTT TQPPPQPPPQ
PQQTLQPKTQ AGAGAKSRPK KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW
FGKPTQRRGM KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN
NMVVRVKWFY HPEETSPGKQ FHEGQHWDQK SGHSLPAALR ASSQRKDFME RALYQSSHVD
ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT YEPTTGMIFS TDGVPVLC
//
