ID TNR4_MOUSE Reviewed; 272 AA.
AC P47741;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 08-NOV-2023, entry version 159.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 4;
DE AltName: Full=OX40 antigen;
DE AltName: Full=OX40L receptor;
DE AltName: CD_antigen=CD134;
DE Flags: Precursor;
GN Name=Tnfrsf4; Synonyms=Ox40, Txgp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=8228223;
RA Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E.,
RA Noelle R.J., Fell H.;
RT "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B
RT cell interactions.";
RL J. Immunol. 151:5261-5271(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7737295; DOI=10.1002/eji.1830250410;
RA Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N.;
RT "Gene structure and chromosomal localization of the mouse homologue of rat
RT OX40 protein.";
RL Eur. J. Immunol. 25:926-930(1995).
RN [3]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=29244194; DOI=10.1002/eji.201747109;
RA Hanieh H., Masuda K., Metwally H., Chalise J.P., Mohamed M., Nyati K.K.,
RA Standley D.M., Li S., Higa M., Zaman M.M., Kishimoto T.;
RT "Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-
RT loop structure in its 3'UTR.";
RL Eur. J. Immunol. 48:593-604(2018).
CC -!- FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule
CC implicated in long-term T-cell immunity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000250}.
CC -!- INTERACTION:
CC P47741; P39429: Traf2; NbExp=12; IntAct=EBI-520001, EBI-520016;
CC P47741; P62991: Ubc; NbExp=3; IntAct=EBI-520001, EBI-413074;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in CD4(+) T-cells and in T-helper Th17
CC cells (at protein level). {ECO:0000269|PubMed:29244194}.
CC -!- INDUCTION: By IL6/STAT3 signaling in T-helper Th17 cells.
CC {ECO:0000269|PubMed:29244194}.
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DR EMBL; Z21674; CAA79772.1; -; mRNA.
DR EMBL; X85214; CAA59476.1; -; Genomic_DNA.
DR CCDS; CCDS19055.1; -.
DR PIR; I48700; I48700.
DR RefSeq; NP_035789.1; NM_011659.2.
DR AlphaFoldDB; P47741; -.
DR SMR; P47741; -.
DR BioGRID; 204386; 1.
DR DIP; DIP-6239N; -.
DR IntAct; P47741; 13.
DR STRING; 10090.ENSMUSP00000030952; -.
DR GlyCosmos; P47741; 1 site, No reported glycans.
DR GlyGen; P47741; 1 site.
DR PhosphoSitePlus; P47741; -.
DR EPD; P47741; -.
DR PaxDb; 10090-ENSMUSP00000030952; -.
DR DNASU; 22163; -.
DR GeneID; 22163; -.
DR KEGG; mmu:22163; -.
DR AGR; MGI:104512; -.
DR CTD; 7293; -.
DR MGI; MGI:104512; Tnfrsf4.
DR eggNOG; ENOG502SB1F; Eukaryota.
DR InParanoid; P47741; -.
DR OrthoDB; 4640065at2759; -.
DR PhylomeDB; P47741; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 22163; 6 hits in 82 CRISPR screens.
DR PRO; PR:P47741; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P47741; Protein.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IPI:MGI.
DR GO; GO:0006968; P:cellular defense response; IMP:MGI.
DR GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IMP:BHF-UCL.
DR GO; GO:0001818; P:negative regulation of cytokine production; IPI:MGI.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IDA:BHF-UCL.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:BHF-UCL.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IMP:BHF-UCL.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IDA:BHF-UCL.
DR GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI.
DR GO; GO:0042098; P:T cell proliferation; ISO:MGI.
DR CDD; cd13406; TNFRSF4; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020445; TNFR_4.
DR InterPro; IPR034022; TNFRSF4_N.
DR PANTHER; PTHR47881; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR47881:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01921; TNFACTORR4.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..272
FT /note="Tumor necrosis factor receptor superfamily member 4"
FT /id="PRO_0000034555"
FT TOPO_DOM 20..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 26..61
FT /note="TNFR-Cys 1"
FT REPEAT 62..103
FT /note="TNFR-Cys 2"
FT REPEAT 104..124
FT /note="TNFR-Cys 3; truncated"
FT REPEAT 125..165
FT /note="TNFR-Cys 4"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..38
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 39..52
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 42..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 63..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 80..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 83..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 105..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 126..139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 145..164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT CONFLICT 15
FT /note="A -> G (in Ref. 2; CAA59476)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 272 AA; 30154 MW; 06E7BB4156F0D08E CRC64;
MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS RCDHTRDTLC
HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD TVCRCRPGTQ PRQDSGYKLG
VDCVPCPPGH FSPGNNQACK PWTNCTLSGK QTRHPASDSL DAVCEDRSLL ATLLWETQRP
TFRPTTVQST TVWPRTSELP SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW
RLPNTPKPCW GNSFRTPIQE EHTDAHFTLA KI
//
