ID TR125_RAT Reviewed; 310 AA.
AC Q67ET4;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Taste receptor type 2 member 125;
DE Short=T2r125;
DE AltName: Full=Taste receptor type 2 member 16;
DE Short=T2R16;
GN Name=Tas2r125 {ECO:0000250|UniProtKB:Q7M710}; Synonyms=T2r16;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13345.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13345.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY362736; AAR13345.1; -; Genomic_DNA.
DR AlphaFoldDB; Q67ET4; -.
DR SMR; Q67ET4; -.
DR GlyCosmos; Q67ET4; 3 sites, No reported glycans.
DR GlyGen; Q67ET4; 3 sites.
DR PhosphoSitePlus; Q67ET4; -.
DR PaxDb; 10116-ENSRNOP00000037096; -.
DR AGR; RGD:1596030; -.
DR RGD; 1596030; Tas2r125.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR InParanoid; Q67ET4; -.
DR PhylomeDB; Q67ET4; -.
DR PRO; PR:Q67ET4; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR CDD; cd15019; 7tm_TAS2R14-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF128; TASTE RECEPTOR TYPE 2-RELATED; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..310
FT /note="Taste receptor type 2 member 125"
FT /id="PRO_0000248484"
FT TOPO_DOM 1..2
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 310 AA; 35639 MW; 4922D67164E78C9E CRC64;
MGIVIGIICA FIIIVQFIIG NVANGFIALV NIIDWVKRRK ISLVDQIITA LAISRIDMLC
STFLIVLITS LYPDLNTAVN MVKISNNIWI VANHFSIWLA TSLSIFYFLK IANFSNYVFL
CLRWRLSKVV SVTLLLSLVL LLMNILIMNM HIDTWSDGFK RNVSFGFRSK NCTRFFKLAL
LINTTFTCVP FTVSMVAFLL LIFSLWRHLK NMQYHAKGSR DPSTAVHIKA LQMVVVFVLF
YTFFFLSLAI QLWTSESLEK NNLFYVTLII TFPSVHSCML ILRNSKLRQA SLLVLWWLLC
RSKDIQTLVP
//
