ID TRUB_SYNPX Reviewed; 291 AA.
AC P59884;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2003, sequence version 1.
DT 01-MAY-2013, entry version 67.
DE RecName: Full=tRNA pseudouridine synthase B;
DE EC=5.4.99.25;
DE AltName: Full=tRNA pseudouridine(55) synthase;
DE Short=Psi55 synthase;
DE AltName: Full=tRNA pseudouridylate synthase;
DE AltName: Full=tRNA-uridine isomerase;
GN Name=truB; OrderedLocusNames=SYNW0544;
OS Synechococcus sp. (strain WH8102).
OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC Synechococcus.
OX NCBI_TaxID=84588;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH8102;
RX PubMed=12917641; DOI=10.1038/nature01943;
RA Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L.,
RA Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J.,
RA Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT "The genome of a motile marine Synechococcus.";
RL Nature 424:1037-1042(2003).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 55 in the psi GC loop of transfer RNAs (By similarity).
CC -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC Type 1 subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BX569690; CAE07059.1; -; Genomic_DNA.
DR RefSeq; NP_896639.1; NC_005070.1.
DR ProteinModelPortal; P59884; -.
DR STRING; 84588.SYNW0544; -.
DR EnsemblBacteria; CAE07059; CAE07059; SYNW0544.
DR GeneID; 1732211; -.
DR KEGG; syw:SYNW0544; -.
DR PATRIC; 23832487; VBISynSp27240_0553.
DR eggNOG; COG0130; -.
DR HOGENOM; HOG000231225; -.
DR KO; K03177; -.
DR OMA; TSHDCVS; -.
DR ProtClustDB; PRK02755; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR HAMAP; MF_01080; TruB_bact; 1; -.
DR InterPro; IPR002501; PsdUridine_synth.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR PANTHER; PTHR13767; PTHR13767; 1.
DR Pfam; PF09142; TruB_C; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00431; TruB; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; tRNA processing.
FT CHAIN 1 291 tRNA pseudouridine synthase B.
FT /FTId=PRO_0000121927.
FT ACT_SITE 41 41 Nucleophile (By similarity).
SQ SEQUENCE 291 AA; 31448 MW; 71BD68FA3DAA35E3 CRC64;
MDGPFGFVVI DKPAGHTSHS CVSRLRRCYG LKRVGHGGTL DPAVTGVLPI ALGPATRLLP
YLPGDKTYRG VIQLGSITSS DDLEGELLRQ APWPDLQPEE LEVALAPFRG PIQQRPPQVS
AVHVDGERAH ARARRGEQMV LPPRPVTIHR LQLLHWDPNQ GQLTLEVHCS AGTYIRSLAR
DLGEQLGCGG CLAQLRRTQA LGFLESQAQA LPEADATPPP PLSPLLALEH LPRRQLTDSE
EADWRCGRRL SLDPGPGDAV VVCNADGSMA GIGLRQEDDQ LQPKVVFDAS G
//
