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Database: UniProt
Entry: TRUB_SYNPX
LinkDB: TRUB_SYNPX
Original site: TRUB_SYNPX 
ID   TRUB_SYNPX              Reviewed;         291 AA.
AC   P59884;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 1.
DT   14-MAY-2014, entry version 71.
DE   RecName: Full=tRNA pseudouridine synthase B;
DE            EC=5.4.99.25;
DE   AltName: Full=tRNA pseudouridine(55) synthase;
DE            Short=Psi55 synthase;
DE   AltName: Full=tRNA pseudouridylate synthase;
DE   AltName: Full=tRNA-uridine isomerase;
GN   Name=truB; OrderedLocusNames=SYNW0544;
OS   Synechococcus sp. (strain WH8102).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Synechococcus.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L.,
RA   Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J.,
RA   Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       55 in the psi GC loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       Type 1 subfamily.
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DR   EMBL; BX569690; CAE07059.1; -; Genomic_DNA.
DR   RefSeq; NP_896639.1; NC_005070.1.
DR   ProteinModelPortal; P59884; -.
DR   STRING; 84588.SYNW0544; -.
DR   EnsemblBacteria; CAE07059; CAE07059; SYNW0544.
DR   GeneID; 1732211; -.
DR   KEGG; syw:SYNW0544; -.
DR   PATRIC; 23832487; VBISynSp27240_0553.
DR   eggNOG; COG0130; -.
DR   HOGENOM; HOG000231225; -.
DR   KO; K03177; -.
DR   OMA; EWFAVKN; -.
DR   OrthoDB; EOG6358D3; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01080; TruB_bact; 1.
DR   InterPro; IPR002501; PsdUridine_synth.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR   InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR   PANTHER; PTHR13767; PTHR13767; 1.
DR   Pfam; PF09142; TruB_C; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00431; TruB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    291       tRNA pseudouridine synthase B.
FT                                /FTId=PRO_0000121927.
FT   ACT_SITE     41     41       Nucleophile (By similarity).
SQ   SEQUENCE   291 AA;  31448 MW;  71BD68FA3DAA35E3 CRC64;
     MDGPFGFVVI DKPAGHTSHS CVSRLRRCYG LKRVGHGGTL DPAVTGVLPI ALGPATRLLP
     YLPGDKTYRG VIQLGSITSS DDLEGELLRQ APWPDLQPEE LEVALAPFRG PIQQRPPQVS
     AVHVDGERAH ARARRGEQMV LPPRPVTIHR LQLLHWDPNQ GQLTLEVHCS AGTYIRSLAR
     DLGEQLGCGG CLAQLRRTQA LGFLESQAQA LPEADATPPP PLSPLLALEH LPRRQLTDSE
     EADWRCGRRL SLDPGPGDAV VVCNADGSMA GIGLRQEDDQ LQPKVVFDAS G
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