ID   TSEP_GLOMM              Reviewed;         320 AA.
AC   Q95P09;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Protein TsetseEP;
DE   AltName: Full=EP-repeat protein;
DE   Flags: Precursor;
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15522612; DOI=10.1016/j.ibmb.2004.07.004;
RA   Chandra M., Liniger M., Tetley L., Roditi I., Barry J.D.;
RT   "TsetseEP, a gut protein from the tsetse Glossina morsitans, is related to
RT   a major surface glycoprotein of trypanosomes transmitted by the fly and to
RT   the products of a Drosophila gene family.";
RL   Insect Biochem. Mol. Biol. 34:1163-1173(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the gut, but not salivary glands, of
CC       female and male flies (at protein level). Present in vesicles in midgut
CC       cells and in the lumen of the gut. {ECO:0000269|PubMed:15522612}.
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DR   EMBL; AJ313389; CAC86027.1; -; mRNA.
DR   AlphaFoldDB; Q95P09; -.
DR   STRING; 37546.Q95P09; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007931; TsetseEP.
DR   PANTHER; PTHR34403:SF8; RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN-LIKE; 1.
DR   PANTHER; PTHR34403; TOL-PAL SYSTEM PROTEIN TOLA; 1.
DR   Pfam; PF05267; DUF725; 1.
PE   1: Evidence at protein level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..320
FT                   /note="Protein TsetseEP"
FT                   /id="PRO_5000067540"
FT   REGION          192..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..311
FT                   /note="59 X 2 AA tandem repeats of P-E"
FT   COMPBIAS        196..305
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  35734 MW;  AC886F8983946504 CRC64;
     MKFFISFAFL CLVLSCVAAL SPDQVESRLK SYVENRSFAL LRSGRVARAG TNTVQCYDKY
     VPLIRQAAAE GKFASDKCAQ EGQNAREEET KKSEVIRESL NVKVASIEKG LGACVAKYDV
     LEYFTCLRDH ASESQTAAGE VGKTSAVIVE GLNIVLTNIE LREKYCIDQA FEQAQEKSDI
     LFTELENCLI EGLPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP
     EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP
     EPEPEPQPEP ESKPNSLFNF
//