ID TVP38_PICGU Reviewed; 349 AA.
AC A5DH87;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Golgi apparatus membrane protein TVP38;
GN Name=TVP38; ORFNames=PGUG_02638;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC spindle migration.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC there is no evidence that this domain associates with SNARE proteins,
CC it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC {ECO:0000250|UniProtKB:P36164}.
CC -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR EMBL; CH408157; EDK38540.2; -; Genomic_DNA.
DR RefSeq; XP_001484909.1; XM_001484859.1.
DR AlphaFoldDB; A5DH87; -.
DR STRING; 294746.A5DH87; -.
DR GlyCosmos; A5DH87; 1 site, No reported glycans.
DR GeneID; 5126612; -.
DR KEGG; pgu:PGUG_02638; -.
DR VEuPathDB; FungiDB:PGUG_02638; -.
DR eggNOG; KOG3140; Eukaryota.
DR HOGENOM; CLU_041954_1_0_1; -.
DR InParanoid; A5DH87; -.
DR OMA; KWQALET; -.
DR OrthoDB; 2385736at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR032816; VTT_dom.
DR PANTHER; PTHR47549:SF1; GOLGI APPARATUS MEMBRANE PROTEIN TVP38; 1.
DR PANTHER; PTHR47549; GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..349
FT /note="Golgi apparatus membrane protein TVP38"
FT /id="PRO_0000343072"
FT TOPO_DOM 1..49
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..123
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..240
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 117..227
FT /note="VTT domain"
FT /evidence="ECO:0000250|UniProtKB:P36164"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 349 AA; 38715 MW; F64E6B6D5503051F CRC64;
MPRLHSASEP PATGFFARVR NELGNRTEGL HQINNQALDW YRSQSQIRQI LIQIGGVVAI
VIGVLVLIFH KYLIELLVII SDDWAKLPGG RLILFLLVFF VGFPPLIGYS ALSLLAGMVY
GFPYGWPLLA SASVSGSFVA FLVFRYFLRS QGERLVNSNE KFRAFAEILR EDSSLFLLVL
IRLCPLPYSL SNGALAAIPE LSAWVYLGAS VITSPKMLIH LFVGHKIKEF GDAKTDTSTK
IIDVISILVT GAAASLTTFI IYRKMQQKLH HNRAGANYDA FVFGNFDDLE SGTNVELNSA
DFDQDNFIIT DDELEEEEPN GSHTATATQV QVARRNCSKA MTICTLMFV
//
