ID U1GE70_ENDPU Unreviewed; 1583 AA.
AC U1GE70;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=EPUS_01278 {ECO:0000313|EMBL:ERF75912.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF75912.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
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DR EMBL; KE720795; ERF75912.1; -; Genomic_DNA.
DR RefSeq; XP_007786761.1; XM_007788571.1.
DR GeneID; 19236336; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_1_1; -.
DR OMA; AAYGHKM; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775:SF53; ATROCHRYSONE CARBOXYLIC ACID SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF16073; SAT; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT DOMAIN 405..839
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1583 AA; 172737 MW; FFD7A56F1660251D CRC64;
MVIYTPSRSD TTFSGSSKMK LVYFSNEFPH DDLQGLLRGL HQHSKDRRHP ILARFLEEAT
LAIRDEVRQL PTSLKALIPP FENILHFADF ADLRKGQLCG SIDGILLCTV ELGTLIGYYE
NSPEAFDFDT VSTSLAGLGI GLLATAAVSL APTVADIPLA GAQVVRQAFR LGVLVDEVSQ
NLQPRDLTDT STPDTWAYVL PDVAADDVQQ ELNAIHAKEK TPEASKVFIS ALSATSVTVS
GPPARLKGIF RTADFFRDRK FVALPVYGGL CHAKHIYNED NVHQVVRTRS MEFLNSRLSP
RIPIHSTSTG RPFPATNATD LFEHIIREIL TQAIQWDSVI QGVIQRAHDI AASQCEVLVF
RISLPIHDLS AALKTLPDFE PSTEELIPWI HEKTTPDGGP RGPMQSKIAI VGMSCRMPGG
ATDTEKFWEL LESGMDVHRK IPADRFDVDS HYDPAGKRIN TSHTPYGCFI DEPGLFDAPF
FNMSPREAQQ TDPMQRLALV TAYEALERAG YVANRTAATD LHRIGTFYGQ ASDDYREVNT
AQEISTYFIP GGCRAFGPGR INYFFKFSGP SYSIDTACSS SLATIQIACT SLWNGDTDTV
VAGGMNVLTN SDAFAGLSHG HFLSKTPNAC KTWDCEADGY CRADAVGSIV MKRLEDAEAD
NDNILGVILA AGTNHSAEAI SITHPHAGHQ AYLGKQVLHR AGIDPLDVSF VEMHGTGTQA
GDAEEIQSVT NVFAPLTKRR STKNPLYIGA VKSNVGHSEA AAGVTALLKV LLMLQKNAIP
PHVGIKNSLN PKFPKDMDKR NVRIPYEKTE WPSVPGKKRV AVVNNFSAAG GNTSLAIEEG
PVREVTETDP RSTHVVALSA KSKISLKGNI ERLLGYLDKN PDVSLAHLSY STTARRYHHN
HRVAIVASDL AQVKKQLTSA LGSVDSHKPI PTTGPPPVAF SFTGQGASHK SSNLDLFHHS
PQFRSQILHL DTLAQGQGFP SFVSAVDGSH PQDYEHSPVI THLALVCTEI ALAKYWASLG
VRPDVVIGHS LGEYAALHVA GVLSASDTIF LVGQRARMLE QKCKVGSHKM VAVRASLAQV
QKSAGDKPYE IACINGPNDT VLSGPVTDMD AIIPVLEADG FKCFSLDVAF AFHSAQTDPI
LDEFEAIANS GVLFQAPHLP VISPLLSKVI FDEKTVNANY MRRATRETVN FLSALETAHK
IGTIDDETAW IEIGPHPVGM GFVKSTLSPV NVAVPSLRRG ENNWKTMAQS LATLHGAGVQ
VGWNEFHRPF EQGLRLLDLP TYAWNDKTYW IQYNGDWALT KGNTFYDAEK GLNKAQIAPP
EPKSSLSTTT VQQIIEQDLN GTAGMVVMQS DLRQVDFRAA AYGHKMNGCG VVTSSIHADI
AYTLGEYLYK LLKPGSKEVH MNIASLEVLK GLVANSKPET PQLIQVSLAT DDIESNTAEL
KWYNVQADGT VDEPFASATL FYGNPAEWLA SWVPTTHLIQ GRIQELERLA ESGIANRFTH
NMAYLLFANN LVDYAEKYRG IQSVVLHGLE AFADVVLTTE KGGSWTVPPY FIDSVAHLAG
FIMNVSDAID TKNNYCTTPG WRV
//
