ID U1GLF8_ENDPU Unreviewed; 575 AA.
AC U1GLF8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Pseudouridine synthase I TruA alpha/beta domain-containing protein {ECO:0000259|Pfam:PF01416};
GN ORFNames=EPUS_04764 {ECO:0000313|EMBL:ERF72711.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF72711.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KE721051; ERF72711.1; -; Genomic_DNA.
DR RefSeq; XP_007801599.1; XM_007803408.1.
DR AlphaFoldDB; U1GLF8; -.
DR GeneID; 19239718; -.
DR eggNOG; KOG2554; Eukaryota.
DR HOGENOM; CLU_014673_2_3_1; -.
DR OMA; SCRERRY; -.
DR OrthoDB; 167554at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 294..433
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 555..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 64953 MW; AD3B46ADFFF861F9 CRC64;
MSAQKTTDYT SWTNADLIAR VADLERQLRQ QNAQILARST SPKRRRIRTQ RANVFDATKY
STRHIALKIA YLGQKYNGYE HANNNITPLP TIEEVLWKAL RKARLISPTS DEGTEVVWSY
AERSRRPLNI NWDGCQYSKG GRTDKGVSAF GQVIGIRVRS NRPTIERPRE ASTNIEIDDE
TVNSDLVASS ELPAVGVDDL GHDVKPSFDP IKDELPYISI LNSLLPSDIR VLAWCPEPPD
DFDARFSCGE RQYKYFFTNP AFLPTPGPIG LKDASGHETD LREGWLDVDA MRTAAKKLVG
LHDFRNFCRV DASKQLTTFE RRITHVDVEE VKQQSGPVAF FEQPQLAKHT NPTHLKPGAL
PTSGPKVYSF TVHGSAFLWH QVRHMVAVLF LVGQRLESPS IVDELLDIEN NRSRPTYDMA
SDAPLVLWDC IFPIDKVQSQ DDGLEWIYAG DARNLEGLTT KGDGKFGLGG IVDEVWSNWR
KHKIDETLAS ALLDRVVCQG DQSALQRGGF RDLETRTYRS QKLFDGSETA RMAGKYVPVM
EKPKMETIDI QNARYRTGKG SRQDTRRAQE LNKDD
//
