ID U1GT93_ENDPU Unreviewed; 1704 AA.
AC U1GT93;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=EPUS_00018 {ECO:0000313|EMBL:ERF75226.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF75226.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
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DR EMBL; KE720815; ERF75226.1; -; Genomic_DNA.
DR RefSeq; XP_007787238.1; XM_007789048.1.
DR GeneID; 19235083; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT DOMAIN 379..507
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1456..1700
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 90..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1704 AA; 185684 MW; FAC4FC2B084A5541 CRC64;
MGLPPSPDSD TSLVSLDPAI VRQISRSKSS HQQLSAKAKQ PFPILASEQH MHESHNTIQY
EPLHGKPPRK IFEKTRKNSL RRVKDSTEVL RQKSTSARHV ANTSDGTSAT ASKGGRHFTV
GNVGTGGKLY LRPTATQPQQ ATPKAFVFPS PTPNSTLHGS LRQENAISGL RQSIWSDSQI
SDKAPNPTAA RSPPLRSKMS DGPPRPSAHI RPFSFSTVDV THQPSAEPKD GVLRIVIDRS
ATTRPKTTEK FALPTLEIPI PHYRLGNPHF SIQGTPLLRS SAYTKTSGGV SENLKPASIL
KTNFLSPERK EEGPSALSKS QTFDTLLSCS GTTSDLSKDP AGAAVSSTSH SQGEPIDPKV
YDRLTSIKDE PCVVRYSQRT GAITAATPAR IVAQISSEAF MDYDLVSDFF LTFRAYLSTE
RLLSLLLARL HWAINRLEDD GRVIRIRTFA ALRHWILNYF VDDFVVNRKL RVQFCDQINE
MYHEVSRRTG GGVSDMKILL DLKRCWNGRC SLYWDSRDFV VTQQDADIVP GGIMGSRDAS
LTQLDIALDQ EIGMTPDNYQ DKVSVTKSWY GSPPVTQGSK THDKHPFTFT AGWPTSPTSE
QSLQPKSCSI PARAFKRTPP PESSARRPYP VSLYQRMQKS PFNLPTSMED SQRRLSNAHK
RSCSTSDSIR DQGSANFVSQ PVYLASPYAG SLIRGNVYPP AAPFVDVIVP ESPPSHKPRL
NASPIGMSTA FDSSAKSGSP TNPGMKTLMG SIRRALSSKQ TGSNSTSSTE EIGPLPPSLH
GKTSNLPLNL ARSTDTLREK KSALASRHHL RIDLLCAAVS QSYQMVQAKA SEESVVNHGL
GVSISGIHES SGSQQTLGSR DFSIEAGDIQ GIPGQDAVRS ASSVLDNTTG NDLPRTITAF
GRDMQGEALV TDLEFAAAGM ASTPILSTER STHQRRSSLE DRRRSSSVDT ALARRSREQG
KMRVARSAGQ PSRIEAYTRR TSSSEPSERL RAAVSPSALL HTDQRQSHAL PHGPYPNFDA
SVASSAMKQS KLEFQSQGHT LRRRPGGNLR NIENVHDLAA GPRRQSTGSL TTQSESVGSM
LVMGGHKVTM SKQKKPALQV AQHPISLIRT HSSQHLRPSF EAAISGFSAI PDDADGGLEA
TLLKLEGRYK HASPEIGIEM GAECARDQTA MVGSSSTDPR QNFDGNASYP QGVQAPISTR
GSNPRLRQPA SASRTRKPGI KTVSARFGQP KSSVADSEES YSSIPLLERG LVGDAVKKPN
AHSKSAPTVS IPSPLLEGQV IVETQRDVAS PHPSIELVEK TESMGRIPHG STLPDVRPLT
ANGSFLLDED DNLTDLSSEM TVDVIEHSEV QAPIVSSPAG APGNVTSGHP LPTHPLAHPP
SPAFSIHQAV TPVPPVNPMM YQQKPLTPQP SPTQGVVAHD SQRSLSQILP PRKSPAVASA
TVTTSAGHIP FVLACESVVL AQQLTLVEKA ALSEIEWSDL VDMKWDNKSP NILNWVEYLA
AKDNRGIDIV ITRFNLVVKW VLSEIVMTQN IYERAQAITK YIHIAGHAKR IHNYATMLQI
TIALTSIDCT RLKATWELVS ESDQVLLREM ETLIQPIRNF HDLRIEMETA NLQDGCIPFV
GLYVHDLTYN AQKPSQIANS LGGEPLVNFE KYRTIATIVK SLLRLIDASS KYNFAPIPGI
IERCLWMAAL SDEKITALSK SIEQ
//