ID U1H219_9PAST Unreviewed; 571 AA.
AC U1H219;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Sensor protein {ECO:0000256|PIRNR:PIRNR003167};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003167};
GN ORFNames=N561_05915 {ECO:0000313|EMBL:ERF78481.1};
OS Gallibacterium anatis 12656/12.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Gallibacterium.
OX NCBI_TaxID=1195244 {ECO:0000313|EMBL:ERF78481.1, ECO:0000313|Proteomes:UP000016529};
RN [1] {ECO:0000313|EMBL:ERF78481.1, ECO:0000313|Proteomes:UP000016529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=12656/12 {ECO:0000313|EMBL:ERF78481.1};
RX PubMed=24115542;
RA Kudirkiene E., Christensen H., Bojesen A.M.;
RT "Draft Genome Sequence of Gallibacterium anatis bv. haemolytica 12656-12
RT Liver, an Isolate Obtained from the Liver of a Septicemic Chicken.";
RL Genome Announc. 1:e00810-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR003167};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERF78481.1}.
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DR EMBL; AVOX01000023; ERF78481.1; -; Genomic_DNA.
DR AlphaFoldDB; U1H219; -.
DR PATRIC; fig|1195244.3.peg.1147; -.
DR Proteomes; UP000016529; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:UniProtKB-UniRule.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR CDD; cd22899; NarQ_sensor; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 1.20.120.960; Histidine kinase NarX, sensor domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR029095; NarX-like_N.
DR InterPro; IPR042295; NarX-like_N_sf.
DR InterPro; IPR016380; Sig_transdc_His_kin_NarX/NarQ.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF66; NITRATE_NITRITE SENSOR PROTEIN NARQ; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13675; PilJ; 1.
DR PIRSF; PIRSF003167; STHK_NarX/NarQ; 2.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Cell inner membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR003167};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR003167};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR003167};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR003167}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..231
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 370..569
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 571 AA; 65151 MW; 53D48C3DBA164EAA CRC64;
MEKNVAKYSV LTRVAKYLIG IILLASFCIS LVFTLLISSQ SDAEAINLAG SLRMQAYRLI
YQMEHEQDTV AHNLQQYTQT LQEKTLNDLQ NSYFVPANVK AAYQNVVNNW QQMSSFVRQQ
QINQYQAQVD QYVAKVDDFV AELQHFSERK IIMAILISIF SIITILVIGS YMLWYMKREV
LNPIEKLVQA STQVQTGHFK HIPLDVDKPN ELGTLSETFT KMASELQKLY WFLEEKVSEK
TKKLSQLNRT LSMLFHTSQK ITHIDLDYNQ LTEVISEIRA SEHLRYIELI VYGAEHLDLS
SGKAEDNYPW QEQKISVNGK LLSCLRWQAG LPCPDLRLMQ SVAQMLGRAI YFIQTQRQQQ
QLVLMEERSI IARELHDSLA QVLAFLQIQL TLLKHALKSS DPQAKEKSFK IIADFEQALN
DGYVQLRELL STFRLTIQEA NLKLALEQVI ESLRNQSDAQ ITLECSLPSQ IFTAQQLVHA
LQVVREALLN AIKHSQATLI EVIAHTNQDG ENEIIVADNG IGIPSLDEPE GHYGLNIMQE
RTAQLNATLT IQRRPTGGTE VKILLANTFT E
//
