ID U1HMW3_ENDPU Unreviewed; 614 AA.
AC U1HMW3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=ATP-dependent RNA helicase MRH4, mitochondrial {ECO:0000256|ARBA:ARBA00039952};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATP-dependent RNA helicase mrh4, mitochondrial {ECO:0000256|ARBA:ARBA00039691};
GN ORFNames=EPUS_05193 {ECO:0000313|EMBL:ERF70374.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF70374.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- FUNCTION: ATP-binding RNA helicase involved in mitochondrial RNA
CC metabolism. Required for maintenance of mitochondrial DNA.
CC {ECO:0000256|ARBA:ARBA00037267}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. MRH4 subfamily.
CC {ECO:0000256|ARBA:ARBA00038507}.
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DR EMBL; KE721319; ERF70374.1; -; Genomic_DNA.
DR RefSeq; XP_007803941.1; XM_007805750.1.
DR AlphaFoldDB; U1HMW3; -.
DR GeneID; 19240146; -.
DR eggNOG; KOG0335; Eukaryota.
DR HOGENOM; CLU_003041_18_0_1; -.
DR OMA; HSTIDFI; -.
DR OrthoDB; 1333884at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47960; DEAD-BOX ATP-DEPENDENT RNA HELICASE 50; 1.
DR PANTHER; PTHR47960:SF1; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:ERF70374.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT DOMAIN 170..385
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 419..614
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 68345 MW; 22BB7EDC178FC06B CRC64;
MATMQRERRK PSRMSLSRDV ARLPRSSEAF RERARPSPFA GMNQTEARLG GRVMVKPRDV
PRPAVGARGA PESTENPRRA KTKDEKPLFH ALKMQATLTP LAYSQRMAVK EKLALITSFE
QFNLLPDVQN AVYTHALEGM TDVVPTPAQK LAIPALLSRK GEHERRKTKD GDRPQYSQFL
IAAETGSGKT LAYLLPVVDA IKRQEIIEKA EEEARKAGED KEKAENQKKN IFALDPPELS
NPPHSTMARP RAIILLPSSE LVTQVGGVVK LLSHTIKYRS APISAIHTPN RIRNRLYDPK
GIDIIVSTPH LISSIAEKDP NILSRVTHLV IDEADSLLDR SFAPTTSAII DRVAPSLKQL
ILCSATIPRS LDSFLDKRFP TIKRLVTPKL HSISRRVQLG VVDIEKDPYR GNRNLACADV
IWTIGKAVHD DTESTHTVKS MLVFVNEREK AVEVTQYLAS KGIDAVALTR DTTEQRQAEV
LSAFTSASRI EGEEKPSATD RSKRNFRDFI PFDQNSIITT LSSPNAAPSR PTRHLPNTKV
LVTTDLGSRG IDTLAVRHVI LYDVPHTTID FVHRLGRMGR MGRRGRGIVL TGKHDRKDVV
AEVKNAMFKG QALI
//