ID U1LMZ5_9GAMM Unreviewed; 761 AA.
AC U1LMZ5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Ribonucleoside-diphosphate reductase {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
DE EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
GN ORFNames=PRUB_17262 {ECO:0000313|EMBL:ERG43717.1};
OS Pseudoalteromonas rubra DSM 6842.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1117318 {ECO:0000313|EMBL:ERG43717.1};
RN [1] {ECO:0000313|EMBL:ERG43717.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29570 {ECO:0000313|EMBL:ERG43717.1};
RX PubMed=22374963; DOI=10.1128/JB.06822-11;
RA Xie B.B., Shu Y.L., Qin Q.L., Rong J.C., Zhang X.Y., Chen X.L., Zhou B.C.,
RA Zhang Y.Z.;
RT "Genome sequence of the cycloprodigiosin-producing bacterial strain
RT Pseudoalteromonas rubra ATCC 29570(T).";
RL J. Bacteriol. 194:1637-1638(2012).
RN [2] {ECO:0000313|EMBL:ERG43717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 29570 {ECO:0000313|EMBL:ERG43717.1};
RA Xie B.-B., Rong J.-C., Qin Q.-L., Shu Y.-L., Zhang Y.-Z.;
RT "Genome sequence of Pseudoalteromonas rubra.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Provides the precursors necessary for DNA synthesis.
CC Catalyzes the biosynthesis of deoxyribonucleotides from the
CC corresponding ribonucleotides. {ECO:0000256|RuleBase:RU003410}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
CC diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
CC diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000206,
CC ECO:0000256|RuleBase:RU003410};
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC chain family. {ECO:0000256|ARBA:ARBA00010406,
CC ECO:0000256|RuleBase:RU003410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERG43717.1}.
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DR EMBL; AHCD02000139; ERG43717.1; -; Genomic_DNA.
DR AlphaFoldDB; U1LMZ5; -.
DR eggNOG; COG0209; Bacteria.
DR OrthoDB; 9762933at2; -.
DR UniPathway; UPA00326; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 1.10.1650.20; -; 1.
DR Gene3D; 3.20.70.20; -; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR013346; NrdE_NrdA_C.
DR InterPro; IPR000788; RNR_lg_C.
DR InterPro; IPR013509; RNR_lsu_N.
DR InterPro; IPR008926; RNR_R1-su_N.
DR InterPro; IPR039718; Rrm1.
DR NCBIfam; TIGR02506; NrdE_NrdA; 1.
DR PANTHER; PTHR11573; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; 1.
DR PANTHER; PTHR11573:SF6; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR Pfam; PF02867; Ribonuc_red_lgC; 1.
DR Pfam; PF00317; Ribonuc_red_lgN; 1.
DR PRINTS; PR01183; RIBORDTASEM1.
DR SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR SUPFAM; SSF48168; R1 subunit of ribonucleotide reductase, N-terminal domain; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
DR PROSITE; PS00089; RIBORED_LARGE; 1.
PE 3: Inferred from homology;
KW Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00492};
KW Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116,
KW ECO:0000256|RuleBase:RU003410};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00492};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003410}.
FT DOMAIN 5..95
FT /note="ATP-cone"
FT /evidence="ECO:0000259|PROSITE:PS51161"
FT REGION 737..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 85732 MW; 84DDE74E7E216C32 CRC64;
MNQQLSVSKR NGRKEPLDLD KIHRVINWAA EGLNNVSVSQ VELKSHIQFY DGIRTEDIHE
TIIKAAADLI SKDTPDYQYL AARLAVFHLR KKAYGQFEPP HLYDHVTKLV EDKRYDAGLL
TDYTREEYEQ LNGFLEHDRD MSFSYAAVKQ LEGKYLVQNR VTGEIYESAQ FLYILVAASL
FSDYPKETRL GYIKRFYDAV SQFKISLPTP IMSGVRTPTR QFSSCVLIET ADSLDSINAT
SSAIVKYVSQ RAGIGVNAGR IRALGSPIRN GEAFHTGCIP FYKHFQTAVK SCSQGGVRGG
AATLFYPLWH LEVENLLVLK NNRGVEENRV RHLDYGVQFN KTMYSRLIKD DYITLFSPSD
VPGLYDAFFE DQEKFERLYV QYEQDESIRK KRIKALELFS MFAQERASTG RIYLQNVDHC
NTHSPFDAKV APIRQSNLCL EIALPTKPLS HVNDEEGEIA LCTLSAFNLG AISSLDELEE
LAELAVRALD NLLDFQDYPV PAAKNATMGR RTLGIGVINF AYYLAKNGVK YSDGSANGLT
HRTFEAIQYY LMKASNKLAQ ERGACPKFNE TTYAKGIMPI DTYKKDVDGI CNEPLHLDWD
GLRQDVMQYG MRNSTLSALM PSETSSQISN ATNGIEPPRG HISVKASKDG ILKQVVPEYE
RLKDNYELLW DIPSNDGYLG LVGIMQKFVD QTISANTNYD PTKFEGGKVP MKLLLKDLLT
AYKLGVKTLY YHNTRDGASD AQDEMKPEAE DDDCAGGACK I
//
