ID U1LUT5_9GAMM Unreviewed; 433 AA.
AC U1LUT5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Alkaline phosphatase {ECO:0000313|EMBL:ERG44876.1};
GN ORFNames=PRUB_12261 {ECO:0000313|EMBL:ERG44876.1};
OS Pseudoalteromonas rubra DSM 6842.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1117318 {ECO:0000313|EMBL:ERG44876.1};
RN [1] {ECO:0000313|EMBL:ERG44876.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29570 {ECO:0000313|EMBL:ERG44876.1};
RX PubMed=22374963; DOI=10.1128/JB.06822-11;
RA Xie B.B., Shu Y.L., Qin Q.L., Rong J.C., Zhang X.Y., Chen X.L., Zhou B.C.,
RA Zhang Y.Z.;
RT "Genome sequence of the cycloprodigiosin-producing bacterial strain
RT Pseudoalteromonas rubra ATCC 29570(T).";
RL J. Bacteriol. 194:1637-1638(2012).
RN [2] {ECO:0000313|EMBL:ERG44876.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 29570 {ECO:0000313|EMBL:ERG44876.1};
RA Xie B.-B., Rong J.-C., Qin Q.-L., Shu Y.-L., Zhang Y.-Z.;
RT "Genome sequence of Pseudoalteromonas rubra.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 1 Mg(2+) ion. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 2 Zn(2+) ions. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- SIMILARITY: Belongs to the alkaline phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005984, ECO:0000256|RuleBase:RU003946}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERG44876.1}.
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DR EMBL; AHCD02000106; ERG44876.1; -; Genomic_DNA.
DR AlphaFoldDB; U1LUT5; -.
DR eggNOG; COG1785; Bacteria.
DR OrthoDB; 9794455at2; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR CDD; cd16012; ALP; 1.
DR Gene3D; 1.10.60.40; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR001952; Alkaline_phosphatase.
DR InterPro; IPR018299; Alkaline_phosphatase_AS.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR PANTHER; PTHR11596; ALKALINE PHOSPHATASE; 1.
DR PANTHER; PTHR11596:SF5; ALKALINE PHOSPHATASE; 1.
DR Pfam; PF00245; Alk_phosphatase; 1.
DR PRINTS; PR00113; ALKPHPHTASE.
DR SMART; SM00098; alkPPc; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR601952-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601952-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR601952-2}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..433
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004614666"
FT ACT_SITE 81
FT /note="Phosphoserine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
FT BINDING 33
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 132
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 134
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 255
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 260
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 264
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 302
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 303
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 397
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
SQ SEQUENCE 433 AA; 46898 MW; 3C38ACA814B6324F CRC64;
MTRKISALAF ALGCTLSNSV FAAPKNIIYM IGDGMGPAFT TAYRYMQDDK ATKVVEPTVF
DSILVGMAHT YPDDDTVVTD SAAGATALST AAKSYNGAIA VDTHKQSLKT MLEIAKEQGM
TTALVATSQI NHATPASFAA HNESRRNYDE IADDYIDNKI AGKLPVDLLL GGGTKYFIRD
DRNLVNEFKE AGYQYADAFD KLDSLSRLPA LGLFAEVAFP HAIDSKEPKR LTSMTNKALG
LLDNHNEKGF FVMIEGSQID WCGHANDIAC AMKEMDDFAG AITAAKAYID KNPDTVLVVT
ADHSTGGLTL GSNGVYQWKT DVVAKAKASV KELTNTLSEA KPKQMAKTWT QLTGLPFDED
TKKALINAQK DSKEALYKAA NKIINDASYT GWTTKGHTAI DVQVFAYGEG RDAFIGSLNN
TQIADKLISY IEK
//
