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Database: UniProt
Entry: U1MPA2_ASCSU
LinkDB: U1MPA2_ASCSU
Original site: U1MPA2_ASCSU 
ID   U1MPA2_ASCSU            Unreviewed;       660 AA.
AC   U1MPA2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 16.
DE   SubName: Full=Eukaryotic translation initiation factor 2d {ECO:0000313|EMBL:ERG86013.1};
GN   ORFNames=ASU_02901 {ECO:0000313|EMBL:ERG86013.1};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Ascaridida;
OC   Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ERG86013.1, ECO:0000313|Proteomes:UP000017900};
RN   [1] {ECO:0000313|EMBL:ERG86013.1, ECO:0000313|Proteomes:UP000017900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Sperm {ECO:0000313|EMBL:ERG86013.1};
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals
RT   conservation, functional diversification, and novel developmental
RT   profiles.";
RL   Genome Res. 21:1462-1477(2011).
RN   [2] {ECO:0000313|EMBL:ERG86013.1, ECO:0000313|Proteomes:UP000017900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Sperm {ECO:0000313|EMBL:ERG86013.1};
RX   PubMed=23123092; DOI=10.1016/j.devcel.2012.09.020;
RA   Wang J., Mitreva M., Berriman M., Thorne A., Magrini V.,
RA   Koutsovoulos G., Kumar S., Blaxter M.L., Davis R.E.;
RT   "Silencing of germline-expressed genes by DNA elimination in somatic
RT   cells.";
RL   Dev. Cell 23:1072-1080(2012).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl
CC       cyclase family. {ECO:0000256|RuleBase:RU000405}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERG86013.1}.
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DR   EMBL; AEUI02000059; ERG86013.1; -; Genomic_DNA.
DR   Proteomes; UP000017900; Unassembled WGS sequence.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.245.10; -; 1.
DR   Gene3D; 2.30.130.10; -; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   SUPFAM; SSF47592; SSF47592; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017900};
KW   Initiation factor {ECO:0000313|EMBL:ERG86013.1};
KW   Lyase {ECO:0000256|RuleBase:RU000405};
KW   Protein biosynthesis {ECO:0000313|EMBL:ERG86013.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017900}.
FT   DOMAIN        1     38       Guanylate cyclase. {ECO:0000259|PROSITE:
FT                                PS50125}.
FT   DOMAIN      215    299       PUA. {ECO:0000259|PROSITE:PS50890}.
FT   DOMAIN      569    642       SUI1. {ECO:0000259|PROSITE:PS50296}.
SQ   SEQUENCE   660 AA;  74647 MW;  0CF1BCB25C28ACF4 CRC64;
     MRIRLGFHTG PVAAGVVGLT APRYCLFGDT VNTASRMEST GVPEMIQISD ATNEQLLKFY
     PEFRTVKRGT IAVKVCYKRR ILFEWLQSKY SAEVEVFPEA SDRKIPKGFE FRRNIRHSDR
     RLSLCTLSCA MFRKSFVVKS NTNMRNSDRR KLLSRLHFAD RISSKAQVAH VRLLNSNGVP
     LNVYTFDKNP LLFEMEDDPN LYPTVYFTWI SPESFPCLLV REQVLSFLEN GADLMLPGVI
     YRRGAFPEFE RNYPVTISVV TNNGHLKGPV GVGVALMSSM EMIANGMQGR GVQILHLYRD
     FLWEFGSRAH PPQIPVPATV VTKPLSEEDF PALDSLTIAN EPNRSVEEKK KSEATNGMEN
     VISDEQIEQQ EPAVEPEPET MEDLAELPLD VGEFYSRYLL PCVPPTRRID MKKTKFKKFS
     VFLNEINSNG DGPIVKITSK SKGVDAIAEK DEVTEDMQAE VKPRIRIDEY FAITEPVLPL
     FRIAAGLSKG DLIETPRVRE IITSYVKNRN LTEKNKVILR DDVLNAVVKH DSEAIDWNTL
     IQKILSRMTK TFVIVTPDGR QMMRKVELPK IAFKTRSGNK KMTLVNNLSL YGIECKPFCQ
     QVQVGIATSA TVVNDAQGCE GPQVTIQGNQ VQFVSELLLN EYGVDKKYMS GLDLIPKKRK
//
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