ID U1PE85_9ACTO Unreviewed; 456 AA.
AC U1PE85;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Aspartate--tRNA ligase {ECO:0000313|EMBL:ERH14925.1};
GN ORFNames=HMPREF1978_01403 {ECO:0000313|EMBL:ERH14925.1};
OS Actinomyces graevenitzii F0530.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1321817 {ECO:0000313|EMBL:ERH14925.1, ECO:0000313|Proteomes:UP000016481};
RN [1] {ECO:0000313|EMBL:ERH14925.1, ECO:0000313|Proteomes:UP000016481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0530 {ECO:0000313|EMBL:ERH14925.1,
RC ECO:0000313|Proteomes:UP000016481};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH14925.1}.
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DR EMBL; AWSC01000058; ERH14925.1; -; Genomic_DNA.
DR AlphaFoldDB; U1PE85; -.
DR PATRIC; fig|1321817.3.peg.1238; -.
DR HOGENOM; CLU_014330_0_1_11; -.
DR Proteomes; UP000016481; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd00777; AspRS_core; 1.
DR Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004524; Asp-tRNA-ligase_1.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR047090; AspRS_core.
DR InterPro; IPR004115; GAD-like_sf.
DR InterPro; IPR029351; GAD_dom.
DR NCBIfam; TIGR00459; aspS_bact; 1.
DR PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF02938; GAD; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF55261; GAD domain-like; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ERH14925.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..423
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT REGION 428..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 50218 MW; 475DE0FCF84F2A82 CRC64;
MQHAIRLRSK VSQAARKVLD AHDFVEIETP TLTRSTPEGA RDFLVPARLA PGCWYALPQS
PQLFKQLLMV AGMERYYQIA RCYRDEDFRA DRQPEFTQLD VEMSFVEQDD VMAVAEDILR
EVWALIGYEL KTPIARMPYR EAMEKYGSDK PDLRFGLELT DLTEFFKDTT FRVFKAPYVG
AVVMPGGASQ SRRTFDAWQE WAKQRGAKGL AYVTVGEDGT LGGPVAKNIT DAERAGLAEA
AGAKPGDCIF FAAGGVDASR ALLGAARLEI GKRCGLIDEN EWSFVWVVDA PLFKPSAEAK
AEGDVALGSS AWTAVHHAFT SPKPEWLDNF DQDPGNALAY AYDIVCNGNE IGGGSIRIHR
RDVQERVFKV MGISQEQAQE KFGFLLDAFK FGAPPHGGIA FGWDRIVSLL THADSIRDVI
AFPKSGGGYD PLTAAPAPIT EQQRKEAGVD AKPEQA
//
