ID U1QAV2_9ACTO Unreviewed; 351 AA.
AC U1QAV2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:ERH19134.1};
GN ORFNames=HMPREF0043_00816 {ECO:0000313|EMBL:ERH19134.1};
OS Actinobaculum sp. oral taxon 183 str. F0552.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinobaculum.
OX NCBI_TaxID=1227261 {ECO:0000313|EMBL:ERH19134.1, ECO:0000313|Proteomes:UP000016495};
RN [1] {ECO:0000313|EMBL:ERH19134.1, ECO:0000313|Proteomes:UP000016495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0552 {ECO:0000313|EMBL:ERH19134.1,
RC ECO:0000313|Proteomes:UP000016495};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Warren W., Mitreva M., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH19134.1}.
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DR EMBL; AWSB01000024; ERH19134.1; -; Genomic_DNA.
DR RefSeq; WP_021602614.1; NZ_KE951461.1.
DR AlphaFoldDB; U1QAV2; -.
DR STRING; 1227261.HMPREF0043_00816; -.
DR PATRIC; fig|1227261.3.peg.723; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_3_11; -.
DR OrthoDB; 9797931at2; -.
DR Proteomes; UP000016495; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08285; NADP_ADH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016495};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 7..351
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 351 AA; 37349 MW; E89AD063FD5D7C3F CRC64;
MKGFAMRSIG RIGWVEKERP VCGPLDAIVR PLAVAPCTSD VHTCWEGAIG ERTDMILGHE
ACGEVVEVGA LVKDFKPGDH VLIPAITPDW SSTETQSGYP MHSGGMLSGW KFSNFKDGVF
GEYFHVNDAD GNLALIPENV SPAEACMLSD MVPTGLHGVE LAQVTFGDDV LVVGIGPVGL
MAVAGANLHG AAHIIGVGSR PVCQEAARSY GATDLVNYRD GAIEDQVMSL TDGRGVDKVV
IAGGDNDTFA SAVKSVRPGG IIGNVNYLGD GEYVRIPRVE WGVGMGHITI TGGLMPGGRL
RMEKLARLVS LGKLNVSRLI THRFQGFEHV EEALWLMKDK PADLIKPVVV L
//
